Downregulation of miR-223 and miR-19a induces differentiation and promotes recruitment of osteoclast cells in giant-cell tumor of the bone via the Runx2/TWIST-RANK/RANKL pathway.

Jiang, Zong-Yuan; Jiang, Jun-Jian; Ma, Yu-Shui; Li, Hong-Ye; Shi, Wei; Fu, Pei-Liang; Xu, Cong-Feng; Lu, Jiu-Zhou; Fu, Da; Xu, Jian-Guang

Jiang, Zong-Yuan; Jiang, Jun-Jian; Ma, Yu-Shui; Li, Hong-Ye; Shi, Wei; Fu, Pei-Liang; Xu, Cong-Feng; Lu, Jiu-Zhou; Fu, Da; Xu, Jian-Guang.

Afiliação

Jiang ZY; Department of Hand Surgery, Shenzhen Longhua District People's Hospital, Shenzhen, 518109, China.
Jiang JJ; Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Ma YS; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, College of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, China.
Li HY; Department of Orthopedics, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China.
Shi W; Department of Hand Surgery, The First Hospital of Taizhou, Wenzhou Medical University, Taizhou, Zhejiang Province, 318020, China.
Fu PL; Department of Joint Surgery and Orthopedic Sports Medicine, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China.
Xu CF; Shanghai Institute of Immunology, Institutes of Medical Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, 200031, China.
Lu JZ; Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China. Electronic address: 071105224@fudan.edu.cn.
Fu D; Central Laboratory for Medical Research, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China. Electronic address: fu800da900@126.com.
Xu JG; Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China. Electronic address: 061101021@fudan.edu.cn.

Biochem Biophys Res Commun ; 505(4): 1003-1009, 2018 11 10.

Article em En | MEDLINE | ID: mdl-30309658

Assuntos

Neoplasias Ósseas/metabolismo; Regulação para Baixo; Tumor de Células Gigantes do Osso/metabolismo; MicroRNAs/metabolismo; Osteoclastos/metabolismo; Neoplasias Ósseas/patologia; Diferenciação Celular; Subunidade alfa 1 de Fator de Ligação ao Core/genética; Subunidade alfa 1 de Fator de Ligação ao Core/metabolismo; Tumor de Células Gigantes do Osso/patologia; Humanos; Proteínas Nucleares/genética; Proteínas Nucleares/metabolismo; Osteoclastos/patologia; Ligante RANK/genética; Ligante RANK/metabolismo; Receptor Ativador de Fator Nuclear kappa-B/genética; Receptor Ativador de Fator Nuclear kappa-B/metabolismo; Células Tumorais Cultivadas; Proteína 1 Relacionada a Twist/genética; Proteína 1 Relacionada a Twist/metabolismo

Palavras-chave

GCT; Osteoclast cells; miR-19a; miR-223

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoclastos / Neoplasias Ósseas / Regulação para Baixo / Tumor de Células Gigantes do Osso / MicroRNAs Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2018 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

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