The significance of MGMT methylation in Glioblastoma Multiforme prognosis.
J Pak Med Assoc
; 68(7): 1137-1139, 2018 Jul.
Article
em En
| MEDLINE
| ID: mdl-30317322
ABSTRACT
Methylation of O6-methylguanine-DNA methyltransferase (MGMT) has been extensively studied as a biomarker in predicting the prognosis of patients with GBM (Glioblastoma multiforme). Its significance has been studied in various subgroups, including age, gender and even race. Correlation between prognosis with MGMT methylation and different treatment regimens has also been studied in detail. There are multiple techniques to analyze MGMT methylation in tumour specimen. We review the current evidence for the importance of MGMT methylation as a biomarker for prognosis in GBM patients, the techniques to analyze it and the effect of epidemiologic factors on its significance.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
/
Metilases de Modificação do DNA
/
Glioblastoma
/
Metilação de DNA
/
Proteínas Supressoras de Tumor
/
Enzimas Reparadoras do DNA
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
J Pak Med Assoc
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Paquistão