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Safety, tolerability, and preliminary efficacy of an IGF-1 mimetic in patients with spinal and bulbar muscular atrophy: a randomised, placebo-controlled trial.
Grunseich, Christopher; Miller, Ram; Swan, Therese; Glass, David J; El Mouelhi, Mohamed; Fornaro, Mara; Petricoul, Olivier; Vostiar, Igor; Roubenoff, Ronenn; Meriggioli, Matthew N; Kokkinis, Angela; Guber, Robert D; Budron, Maher S; Vissing, John; Soraru, Gianni; Mozaffar, Tahseen; Ludolph, Albert; Kissel, John T; Fischbeck, Kenneth H.
Afiliação
  • Grunseich C; Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. Electronic address: christopher.grunseich@nih.gov.
  • Miller R; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Swan T; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • Glass DJ; Novartis Institutes for Biomedical Research, Cambridge, MA, USA.
  • El Mouelhi M; Novartis Institutes for Biomedical Research, East Hanover, NJ, USA.
  • Fornaro M; Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Petricoul O; Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Vostiar I; Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Roubenoff R; Novartis Institutes for Biomedical Research, Basel, Switzerland.
  • Meriggioli MN; AveXis Inc, Bannockburn, IL, USA.
  • Kokkinis A; Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Guber RD; Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Budron MS; Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Vissing J; Copenhagen Neuromuscular Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  • Soraru G; Department of Neuroscience, University of Padova, Padova, Italy.
  • Mozaffar T; University of California Irvine, ALS and Neuromuscular Center, Orange, CA, USA.
  • Ludolph A; Department of Neurology, University of Ulm, Ulm, Germany.
  • Kissel JT; Department of Neurology, Wexner Medical Center, Ohio State University, Columbus, OH, USA.
  • Fischbeck KH; Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Lancet Neurol ; 17(12): 1043-1052, 2018 12.
Article em En | MEDLINE | ID: mdl-30337273
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Crescimento Insulin-Like I / Atrofia Muscular / Resultado do Tratamento / Atrofia Bulboespinal Ligada ao X Tipo de estudo: Clinical_trials / Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Neurol Assunto da revista: NEUROLOGIA Ano de publicação: 2018 Tipo de documento: Article País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Crescimento Insulin-Like I / Atrofia Muscular / Resultado do Tratamento / Atrofia Bulboespinal Ligada ao X Tipo de estudo: Clinical_trials / Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Neurol Assunto da revista: NEUROLOGIA Ano de publicação: 2018 Tipo de documento: Article País de publicação: Reino Unido