Evaluation of Porcine Hybrid Bone Block for Bone Grafting in Dentistry.

ABSTRACT

BACKGROUND/AIM: The purpose of this study was to develop hybrid bone blocks using porcine-derived collagen and low crystalline porcine-derived hydroxyapatite to overcome the disadvantages of commonly used bone grafts in dentistry. MATERIALS AND METHODS: Collagen was added to hydroxyapatite particles to increase the spatial integration of particulate bone grafts. Physicochemical examination and in vivo tests were performed to analyze scaffold's characteristics and evaluate bone regeneration. RESULTS: Porcine hybrid bone block had an irregular and interconnecting macroporous structure that was adequate for bone regeneration and bone ingrowth, and showed a good space-occupying ability to become well positioned. In addition, it showed higher angiogenesis and biodegradability than Bio-Oss Collagen®, a commercialized bone graft used in dental clinics. CONCLUSION: Our results suggest that improved collagen hybrid bone block can be generated when porcine cancellous bone particles and collagen were reasonably mixed. This hybrid bone block was easy in handling had flexibility, good biodegradability and provided bone regeneration.