Prenatal and postnatal experiences associated with epigenetic changes in the adult mouse brain.
Behav Brain Res
; 359: 143-148, 2019 02 01.
Article
em En
| MEDLINE
| ID: mdl-30385366
ABSTRACT
To analyze the influences of early-life history on the brain epigenome, the offspring of mouse dams kept in an enriched or standard environment were exposed postnatally to enriched, standard, or adverse conditions. The methylation patterns of 7 candidate genes (9 loci) involved in developmental programming of stress vulnerability/resilience and psychiatric disease were analyzed in 6 brain regions of adult male and female mice. Exposure to an enriched prenatal environment was associated with widespread epigenetic changes (all of small effect size), affecting 29 of 324 (9%) gene/region-specific methylation patterns. The effects of either adverse or enriched postnatal conditions were tested separately in the two prenatal cohorts. Significant changes were observed in 2 of 324 (0.6%) loci in offspring of dams in a standard environment and 6 of 324 (1.9%) loci in animals that were exposed prenatally to an enriched environment. Prenatal life experiences appear to have a bigger effect on the adult brain epigenome than postnatal experiences. Positive prenatal life experiences may increase epigenetic plasticity of the brain later in life. All observed between-group differences were sex-specific, consistent with largely different developmental trajectories of the male and female brain. Multiple changes of small effect size are consistent with a multifactorial model of developmental programming of adult behavior and disease susceptibility.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
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Estresse Psicológico
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Encéfalo
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Epigênese Genética
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Meio Ambiente
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Animals
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Pregnancy
Idioma:
En
Revista:
Behav Brain Res
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Alemanha