Antinuclear antibodies in Frontotemporal Dementia: the tip's of autoimmunity iceberg?
J Neuroimmunol
; 325: 61-63, 2018 12 15.
Article
em En
| MEDLINE
| ID: mdl-30391902
ABSTRACT
Recent studies suggest a role of the autoimmune system dysregulation in Frontotemporal dementia (FTD). In the present study, we performed a broad immunological screening in a large sample of sporadic FTD patients. We reported a significant increase of antinuclear autoantibodies (ANA) positivity in 100 FTD patients as compared to 100 healthy controls (HC) (60% vs. 13%, pâ¯<â¯.001). In FTD, ANA-positive and ANA-negative patients did not differ for any clinical feature. These data extend and further confirm autoimmune dysregulation in FTD. However, it still remains to be clarified whether these antibodies have a potential pathogenic role or represent simply an epiphenomenon.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoimunidade
/
Anticorpos Antinucleares
/
Demência Frontotemporal
Tipo de estudo:
Diagnostic_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Itália