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Isogenic Pairs of hiPSC-CMs with Hypertrophic Cardiomyopathy/LVNC-Associated ACTC1 E99K Mutation Unveil Differential Functional Deficits.
Smith, James G W; Owen, Thomas; Bhagwan, Jamie R; Mosqueira, Diogo; Scott, Elizabeth; Mannhardt, Ingra; Patel, Asha; Barriales-Villa, Roberto; Monserrat, Lorenzo; Hansen, Arne; Eschenhagen, Thomas; Harding, Sian E; Marston, Steve; Denning, Chris.
Afiliação
  • Smith JGW; Wolfson Centre for Stem Cells, Tissue Engineering and Modelling, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK; Faculty of Medicine and Health Sciences, Norwich Medical School, University of East Anglia, Norwich Research Park, Norwich NR4 7UQ, UK
  • Owen T; National Heart and Lung Institute, Imperial College, London W12 0NN, UK.
  • Bhagwan JR; Wolfson Centre for Stem Cells, Tissue Engineering and Modelling, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
  • Mosqueira D; Wolfson Centre for Stem Cells, Tissue Engineering and Modelling, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
  • Scott E; Wolfson Centre for Stem Cells, Tissue Engineering and Modelling, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
  • Mannhardt I; Institute of Experimental Pharmacology and Toxicology, University Medical Centre, Hamburg-Eppendorf, Hamburg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany.
  • Patel A; Wolfson Centre for Stem Cells, Tissue Engineering and Modelling, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK; Department of Gene Therapy, National Heart and Lung Institute, Imperial College London SW3 6LR, UK.
  • Barriales-Villa R; Inherited Cardiovascular Diseases Unit, Cardiology Service, Complexo Hospitalario Universitario A Coruña, Servizo Galego de Saúde (SERGAS), Universidade da Coruña, A Coruña, Spain; Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Spain.
  • Monserrat L; Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Spain; Health in Code S.L., Cardiology Department, A Coruña, Spain.
  • Hansen A; Institute of Experimental Pharmacology and Toxicology, University Medical Centre, Hamburg-Eppendorf, Hamburg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany.
  • Eschenhagen T; Institute of Experimental Pharmacology and Toxicology, University Medical Centre, Hamburg-Eppendorf, Hamburg, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany.
  • Harding SE; National Heart and Lung Institute, Imperial College, London W12 0NN, UK.
  • Marston S; National Heart and Lung Institute, Imperial College, London W12 0NN, UK.
  • Denning C; Wolfson Centre for Stem Cells, Tissue Engineering and Modelling, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham NG7 2RD, UK. Electronic address: chris.denning@nottingham.ac.uk.
Stem Cell Reports ; 11(5): 1226-1243, 2018 11 13.
Article em En | MEDLINE | ID: mdl-30392975
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cardiomiopatia Hipertrófica / Actinas / Miócitos Cardíacos / Células-Tronco Pluripotentes Induzidas / Mutação Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Stem Cell Reports Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cardiomiopatia Hipertrófica / Actinas / Miócitos Cardíacos / Células-Tronco Pluripotentes Induzidas / Mutação Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Stem Cell Reports Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Estados Unidos