Activity of rifabutin alone or in combination with clofazimine or ethambutol or both against acute and chronic experimental Mycobacterium intracellulare infections.
Am Rev Respir Dis
; 136(2): 329-33, 1987 Aug.
Article
em En
| MEDLINE
| ID: mdl-3039879
ABSTRACT
Rifabutin (ansamycin LM 427) when given alone in doses of 5, 10, or 20 mg/kg showed limited in vivo activity against acute or chronic Mycobacterium intracellulare infections studied in beige C57B1/6, or S/W mice. Prophylactic studies in S/W mice in which chemotherapy was given for 3 wk prior to challenge showed slight improvement. Combination chemotherapy consisting of rifabutin (10 mg/kg) and clofazimine (20 mg/kg) achieved complete sterilization of M. intracellulare infections in spleen and lung when initiated immediately after challenge. Inclusion of ethambutol did not offer additional benefit. If chemotherapy is initiated 3 wk after challenge (established infections), the activity of this double drug combination is less effective.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rifamicinas
/
Tuberculose
/
Clofazimina
/
Etambutol
Limite:
Animals
Idioma:
En
Revista:
Am Rev Respir Dis
Ano de publicação:
1987
Tipo de documento:
Article