PA28&#945;ß overexpression enhances learning and memory of female mice without inducing 20S proteasome activity.

Adelöf, Julia; Andersson, My; Porritt, Michelle; Petersen, Anne; Zetterberg, Madeleine; Wiseman, John; Hernebring, Malin

PA28αß overexpression enhances learning and memory of female mice without inducing 20S proteasome activity.

Adelöf, Julia; Andersson, My; Porritt, Michelle; Petersen, Anne; Zetterberg, Madeleine; Wiseman, John; Hernebring, Malin.

Afiliação

Adelöf J; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Andersson M; IMED Biotech Unit, Discovery Biology, Discovery Sciences, AstraZeneca, Gothenburg, Sweden.
Porritt M; Department of Clinical Sciences, Epilepsy Centre, Lund University, Lund, Sweden.
Petersen A; IMED Biotech Unit, Discovery Biology, Discovery Sciences, AstraZeneca, Gothenburg, Sweden.
Zetterberg M; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Wiseman J; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Hernebring M; IMED Biotech Unit, Discovery Biology, Discovery Sciences, AstraZeneca, Gothenburg, Sweden.

BMC Neurosci ; 19(1): 70, 2018 Nov 06.

Article em En | MEDLINE | ID: mdl-30400847

Assuntos

Aprendizagem/fisiologia; Complexo de Endopeptidases do Proteassoma/metabolismo; Animais; Depressão/metabolismo; Receptor beta de Estrogênio/metabolismo; Estrogênios/sangue; Feminino; Expressão Gênica; Técnicas de Introdução de Genes; Hipocampo/metabolismo; Homeostase/fisiologia; Camundongos Endogâmicos BALB C; Camundongos Endogâmicos C57BL; Complexo de Endopeptidases do Proteassoma/genética

Palavras-chave

20S proteasome; Behavioral phenotyping; F2 hybrid transgenic mice; K48-linked protein ubiquitination; Learning and memory; PA28αß; Proteasome capacity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complexo de Endopeptidases do Proteassoma / Aprendizagem Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: BMC Neurosci Assunto da revista: NEUROLOGIA Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Suécia País de publicação: Reino Unido

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