Highly Sensitive Label-Free Detection of Small Molecules with an Optofluidic Microbubble Resonator.
Micromachines (Basel)
; 9(6)2018 May 31.
Article
em En
| MEDLINE
| ID: mdl-30424207
ABSTRACT
The detection of small molecules has increasingly attracted the attention of researchers because of its important physiological function. In this manuscript, we propose a novel optical sensor which uses an optofluidic microbubble resonator (OFMBR) for the highly sensitive detection of small molecules. This paper demonstrates the binding of the small molecule biotin to surface-immobilized streptavidin with a detection limit reduced to 0.41 pM. Furthermore, binding specificity of four additional small molecules to surface-immobilized streptavidin is shown. A label-free OFMBR-based optical sensor has great potential in small molecule detection and drug screening because of its high sensitivity, low detection limit, and minimal sample consumption.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Micromachines (Basel)
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
China