Autonomic nervous system assessment by pupillary response as a potential biomarker for cardiovascular risk: A pilot study.
J Clin Neurosci
; 59: 41-46, 2019 Jan.
Article
em En
| MEDLINE
| ID: mdl-30448298
ABSTRACT
BACKGROUND:
Cardiovascular risk (CVR) biomarkers are of increasing interest because of their potential utility in management of cardiovascular diseases. The activity of the autonomic nervous system (ANS) is known to be highly correlated with CVR and therefore, is a putative biomarker. Common ANS measurement tools have several technological limitations and high-variance signals. The pupillary responses (PR) is controlled by both components of the ANS, and recent advances in pupillometry are making this measurement, easy and reliable. Thus, PR assessment could become a useful clinical tool to measure the ANS modulation and its relation to CVR. Here, we aimed to evaluate differences in PR between low CVR and moderate/high CVR individuals.METHODS:
We performed a cross-sectional study. We recruited voluntaries with low CVR (group 1, nâ¯=â¯12) and patients with moderate/high CVR (group 2, nâ¯=â¯7). An eye tracker was used to measure PR to different visual stimulus that included colors (white, black, gray) and images with known emotional valence (pleasant, unpleasant and neutrals), which were intercalated by pink "noise" images. Differences in PR between both CVR groups were assessed by Mann Whitney U test of different epochs of the PR.RESULTS:
PR was significantly different between both CVR groups (p-valueâ¯<â¯0,05) when the observed images were unpleasant, neutral, and pink noise, for different epochs of the PR.CONCLUSIONS:
This is the first study that demonstrates that PR is different according to CVR. Thus, PR could be considered as a novel biomarker of CVR to be tested in prospective studies.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reflexo Pupilar
/
Sistema Nervoso Autônomo
/
Doenças Cardiovasculares
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Neurosci
Assunto da revista:
NEUROLOGIA
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Chile