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Small-Molecule Allosteric Triggers of Clostridium difficile Toxin B Auto-proteolysis as a Therapeutic Strategy.
Ivarsson, Mattias E; Durantie, Estelle; Huberli, Corina; Huwiler, Samuel; Hegde, Chrismita; Friedman, Jillian; Altamura, Fernando; Lu, Jun; Verdu, Elena F; Bercik, Premysl; Logan, Susan M; Chen, Wangxue; Leroux, Jean-Christophe; Castagner, Bastien.
Afiliação
  • Ivarsson ME; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, Zurich 8093, Switzerland.
  • Durantie E; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, Zurich 8093, Switzerland.
  • Huberli C; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, Zurich 8093, Switzerland.
  • Huwiler S; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, Zurich 8093, Switzerland.
  • Hegde C; Department of Pharmacology & Therapeutics, Microbiome & Disease Tolerance Centre, McGill University, 3655 Prom. Sir-William-Osler, Montreal, QC H3G 1Y6, Canada.
  • Friedman J; Department of Pharmacology & Therapeutics, Microbiome & Disease Tolerance Centre, McGill University, 3655 Prom. Sir-William-Osler, Montreal, QC H3G 1Y6, Canada.
  • Altamura F; Department of Pharmacology & Therapeutics, Microbiome & Disease Tolerance Centre, McGill University, 3655 Prom. Sir-William-Osler, Montreal, QC H3G 1Y6, Canada.
  • Lu J; Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8, Canada.
  • Verdu EF; Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8, Canada.
  • Bercik P; Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8, Canada.
  • Logan SM; Human Health Therapeutics, National Research Council Canada, 100 Sussex Drive, Ottawa, ON K1A 0R6, Canada.
  • Chen W; Human Health Therapeutics, National Research Council Canada, 100 Sussex Drive, Ottawa, ON K1A 0R6, Canada.
  • Leroux JC; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1-5/10, Zurich 8093, Switzerland.
  • Castagner B; Department of Pharmacology & Therapeutics, Microbiome & Disease Tolerance Centre, McGill University, 3655 Prom. Sir-William-Osler, Montreal, QC H3G 1Y6, Canada. Electronic address: bastien.castagner@mcgill.ca.
Cell Chem Biol ; 26(1): 17-26.e13, 2019 01 17.
Article em En | MEDLINE | ID: mdl-30482680

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Fítico / Proteínas de Bactérias / Toxinas Bacterianas / Clostridioides difficile / Infecções por Clostridium / Bibliotecas de Moléculas Pequenas / Inflamação Limite: Animals Idioma: En Revista: Cell Chem Biol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Suíça País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ácido Fítico / Proteínas de Bactérias / Toxinas Bacterianas / Clostridioides difficile / Infecções por Clostridium / Bibliotecas de Moléculas Pequenas / Inflamação Limite: Animals Idioma: En Revista: Cell Chem Biol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Suíça País de publicação: Estados Unidos