Inhibitory Activities of Essential Oil Obtained from Turmeric and Its Constituents against ß-Secretase.
Nat Prod Commun
; 11(12): 1785-1788, 2016 Dec.
Article
em En
| MEDLINE
| ID: mdl-30508333
The need for a preventive agent against dementia led us to screen natural plant resources. Among the herbs and spices tested, turmeric, from rhizomes of Curcuma longa, showed high potency against ß-secretase. The active principles were determined as α-turmerone, ß-turmerone and ar-turmerone, with IC(50) values of 39, 62 and 92 µM respectively. In this study, the efficiency of collecting the essential oil using steam distillation of the volatile substance was disclosed The active principles were explored, and four sesquiterpenoids and five monoterpenoids were revealed as active principles against ß-secretase; On the other hand, α-turmerone, ß-turmerone and ar-turmerone were also investigated in a pharmacokinetic absorption experiment. After oral administration, these compounds were detected in an intact form in the brain and serum. These results suggest that consumption of-turieric constituents may prevent dementia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Óleos Voláteis
/
Curcuma
/
Secretases da Proteína Precursora do Amiloide
/
Cetonas
Limite:
Animals
Idioma:
En
Revista:
Nat Prod Commun
Assunto da revista:
BOTANICA
/
FARMACOLOGIA
/
QUIMICA
Ano de publicação:
2016
Tipo de documento:
Article
País de publicação:
Estados Unidos