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DHS (trans-4,4'-dihydroxystilbene) suppresses DNA replication and tumor growth by inhibiting RRM2 (ribonucleotide reductase regulatory subunit M2).
Chen, Chi-Wei; Li, Yongming; Hu, Shuya; Zhou, Wei; Meng, Yunxiao; Li, Zongzhu; Zhang, Yi; Sun, Jing; Bo, Zhou; DePamphilis, Melvin L; Yen, Yun; Han, Zhiyong; Zhu, Wenge.
Afiliação
  • Chen CW; Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
  • Li Y; GW Cancer Center, The George Washington University, Washington, DC, USA.
  • Hu S; Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
  • Zhou W; College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
  • Meng Y; City of Hope National Medical Center, Duarte, CA, USA.
  • Li Z; Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
  • Zhang Y; GW Cancer Center, The George Washington University, Washington, DC, USA.
  • Sun J; Department of Colorectal Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Bo Z; Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
  • DePamphilis ML; GW Cancer Center, The George Washington University, Washington, DC, USA.
  • Yen Y; Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
  • Han Z; GW Cancer Center, The George Washington University, Washington, DC, USA.
  • Zhu W; Department of Biochemistry and Molecular Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Oncogene ; 38(13): 2364-2379, 2019 03.
Article em En | MEDLINE | ID: mdl-30518875

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribonucleotídeo Redutases / Estilbenos / Proliferação de Células / Replicação do DNA / Neoplasias Limite: Animals / Female / Humans Idioma: En Revista: Oncogene Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ribonucleotídeo Redutases / Estilbenos / Proliferação de Células / Replicação do DNA / Neoplasias Limite: Animals / Female / Humans Idioma: En Revista: Oncogene Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos