Versatile Polymeric Microspheres with Tumor Microenvironment Bioreducible Degradation, pH-Activated Surface Charge Reversal, pH-Triggered "off-on" Fluorescence and Drug Release as Theranostic Nanoplatforms.

Pei, Mingliang; Jia, Xu; Li, Guoping; Liu, Peng

Pei, Mingliang; Jia, Xu; Li, Guoping; Liu, Peng.

Afiliação

Pei M; State Key Laboratory of Applied Organic Chemistry and Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering , Lanzhou University , Lanzhou 730000 , China.
Jia X; State Key Laboratory of Applied Organic Chemistry and Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering , Lanzhou University , Lanzhou 730000 , China.
Li G; State Key Laboratory of Applied Organic Chemistry and Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering , Lanzhou University , Lanzhou 730000 , China.
Liu P; State Key Laboratory of Applied Organic Chemistry and Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering , Lanzhou University , Lanzhou 730000 , China.

Mol Pharm ; 16(1): 227-237, 2019 01 07.

Article em En | MEDLINE | ID: mdl-30525642

Assuntos

Microesferas; Polímeros/química; Células A549; Citometria de Fluxo; Fluorescência; Células Hep G2; Humanos; Concentração de Íons de Hidrogênio; Células MCF-7; Metacrilatos/química; Microscopia Eletrônica de Transmissão; Polietilenoglicóis/química; Espectroscopia de Infravermelho com Transformada de Fourier

Palavras-chave

pH-activated surface charge reversal; pH-triggered drug release; pH-triggered "off−on" fluorescence; polymeric microspheres; theranostic nanoplatforms; tumor microenvironment bioreducible degradation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Polímeros / Microesferas Limite: Humans Idioma: En Revista: Mol Pharm Assunto da revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

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