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Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS.
Sengupta-Ghosh, Arundhati; Dominguez, Sara L; Xie, Luke; Barck, Kai H; Jiang, Zhiyu; Earr, Timothy; Imperio, Jose; Phu, Lilian; Budayeva, Hanna G; Kirkpatrick, Donald S; Cai, Hao; Eastham-Anderson, Jeffrey; Ngu, Hai; Foreman, Oded; Hedehus, Maj; Reichelt, Michael; Hotzel, Isidro; Shang, Yonglei; Carano, Richard A D; Ayalon, Gai; Easton, Amy.
Afiliação
  • Sengupta-Ghosh A; Departments of Neuroscience, Genentech, South San Francisco, CA, USA.
  • Dominguez SL; Departments of Neuroscience, Genentech, South San Francisco, CA, USA.
  • Xie L; Departments of Biomedical Imaging, Genentech, South San Francisco, CA, USA.
  • Barck KH; Departments of Biomedical Imaging, Genentech, South San Francisco, CA, USA.
  • Jiang Z; Departments of Neuroscience, Genentech, South San Francisco, CA, USA.
  • Earr T; Departments of Neuroscience, Genentech, South San Francisco, CA, USA.
  • Imperio J; Departments of Neuroscience, Genentech, South San Francisco, CA, USA.
  • Phu L; Departments of Microchemistry, Proteomics, and Lipidomics, Genentech, South San Francisco, CA, USA.
  • Budayeva HG; Departments of Microchemistry, Proteomics, and Lipidomics, Genentech, South San Francisco, CA, USA.
  • Kirkpatrick DS; Departments of Microchemistry, Proteomics, and Lipidomics, Genentech, South San Francisco, CA, USA.
  • Cai H; Departments of Preclinical and Translational Pharmacokinetics, Genentech, South San Francisco, CA, USA.
  • Eastham-Anderson J; Departments of Pathology, Genentech, South San Francisco, CA, USA.
  • Ngu H; Departments of Pathology, Genentech, South San Francisco, CA, USA.
  • Foreman O; Departments of Pathology, Genentech, South San Francisco, CA, USA.
  • Hedehus M; Departments of Biomedical Imaging, Genentech, South San Francisco, CA, USA.
  • Reichelt M; Departments of Pathology, Genentech, South San Francisco, CA, USA.
  • Hotzel I; Departments of Antibody Discovery, Genentech, South San Francisco, CA, USA.
  • Shang Y; Departments of Antibody Discovery, Genentech, South San Francisco, CA, USA.
  • Carano RAD; Departments of Biomedical Imaging, Genentech, South San Francisco, CA, USA.
  • Ayalon G; Departments of Neuroscience, Genentech, South San Francisco, CA, USA.
  • Easton A; Departments of Neuroscience, Genentech, South San Francisco, CA, USA. Electronic address: easton.amy@gene.com.
Neurobiol Dis ; 124: 340-352, 2019 04.
Article em En | MEDLINE | ID: mdl-30528255
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diafragma / Receptores Proteína Tirosina Quinases / Esclerose Lateral Amiotrófica / Junção Neuromuscular Limite: Animals Idioma: En Revista: Neurobiol Dis Assunto da revista: NEUROLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diafragma / Receptores Proteína Tirosina Quinases / Esclerose Lateral Amiotrófica / Junção Neuromuscular Limite: Animals Idioma: En Revista: Neurobiol Dis Assunto da revista: NEUROLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos