Loperamide overcomes the resistance of colon cancer cells to bortezomib by inducing CHOP-mediated paraptosis-like cell death.

Kim, In Young; Shim, Min June; Lee, Dong Min; Lee, A Reum; Kim, Mi Ae; Yoon, Mi Jin; Kwon, Mi Ri; Lee, Hae In; Seo, Min Ji; Choi, Yong Won; Choi, Kyeong Sook

Kim, In Young; Shim, Min June; Lee, Dong Min; Lee, A Reum; Kim, Mi Ae; Yoon, Mi Jin; Kwon, Mi Ri; Lee, Hae In; Seo, Min Ji; Choi, Yong Won; Choi, Kyeong Sook.

Afiliação

Kim IY; Department of Biochemistry and Molecular Biology, Ajou University, Suwon 16499, Republic of Korea.
Shim MJ; Department of Biochemistry and Molecular Biology, Ajou University, Suwon 16499, Republic of Korea; Department of Biomedical Science, Ajou University Graduate School of Medicine, Suwon 16499, Republic of Korea.
Lee DM; Department of Biochemistry and Molecular Biology, Ajou University, Suwon 16499, Republic of Korea; Department of Biomedical Science, Ajou University Graduate School of Medicine, Suwon 16499, Republic of Korea.
Lee AR; Department of Biochemistry and Molecular Biology, Ajou University, Suwon 16499, Republic of Korea; Department of Biomedical Science, Ajou University Graduate School of Medicine, Suwon 16499, Republic of Korea.
Kim MA; Department of Biochemistry and Molecular Biology, Ajou University, Suwon 16499, Republic of Korea; Department of Biomedical Science, Ajou University Graduate School of Medicine, Suwon 16499, Republic of Korea.
Yoon MJ; Department of Biochemistry and Molecular Biology, Ajou University, Suwon 16499, Republic of Korea.
Kwon MR; Department of Biochemistry and Molecular Biology, Ajou University, Suwon 16499, Republic of Korea; Department of Biomedical Science, Ajou University Graduate School of Medicine, Suwon 16499, Republic of Korea.
Lee HI; Department of Biochemistry and Molecular Biology, Ajou University, Suwon 16499, Republic of Korea; Department of Biomedical Science, Ajou University Graduate School of Medicine, Suwon 16499, Republic of Korea.
Seo MJ; Department of Biochemistry and Molecular Biology, Ajou University, Suwon 16499, Republic of Korea; Department of Biomedical Science, Ajou University Graduate School of Medicine, Suwon 16499, Republic of Korea.
Choi YW; Department of Hematology-Oncology, Ajou University School of Medicine, Suwon 16499, Republic of Korea.
Choi KS; Department of Biochemistry and Molecular Biology, Ajou University, Suwon 16499, Republic of Korea; Department of Biomedical Science, Ajou University Graduate School of Medicine, Suwon 16499, Republic of Korea. Electronic address: kschoi@ajou.ac.kr.

Biochem Pharmacol ; 162: 41-54, 2019 04.

Article em En | MEDLINE | ID: mdl-30529689

Assuntos

Antineoplásicos/farmacologia; Protocolos de Quimioterapia Combinada Antineoplásica/farmacologia; Apoptose/efeitos dos fármacos; Bortezomib/farmacologia; Neoplasias do Colo/patologia; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Loperamida/farmacologia; Antidiarreicos/farmacologia; Apoptose/fisiologia; Morte Celular/efeitos dos fármacos; Morte Celular/fisiologia; Ciclofosfamida/farmacologia; Relação Dose-Resposta a Droga; Doxorrubicina/farmacologia; Resistencia a Medicamentos Antineoplásicos/fisiologia; Células HCT116; Células HeLa; Humanos; Prednisona/farmacologia; Inibidores de Proteassoma/farmacologia; Vincristina/farmacologia

Palavras-chave

Bortezomib; CHOP; ER stress; Loperamide; Paraptosis-like cell death

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Protocolos de Quimioterapia Combinada Antineoplásica / Apoptose / Neoplasias do Colo / Resistencia a Medicamentos Antineoplásicos / Bortezomib / Loperamida / Antineoplásicos Limite: Humans Idioma: En Revista: Biochem Pharmacol Ano de publicação: 2019 Tipo de documento: Article País de publicação: Reino Unido

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