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Gene-gene and gene-environment interaction data for platinum-based chemotherapy in non-small cell lung cancer.
Wang, Lei-Yun; Cui, Jia-Jia; Liu, Jun-Yan; Guo, Ao-Xiang; Zhao, Zhen-Yu; Liu, Ying-Zi; Wu, Ji-Chu; Li, Min; Hu, Cheng-Ping; Gao, Yang; Zhou, Hong-Hao; Yin, Ji-Ye.
Afiliação
  • Wang LY; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China.
  • Cui JJ; Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China.
  • Liu JY; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China.
  • Guo AX; Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China.
  • Zhao ZY; Department of orthopaedics, The First Affiliated Hospital of the University of South China, Hengyang 421001, P. R. China.
  • Liu YZ; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China.
  • Wu JC; Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China.
  • Li M; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China.
  • Hu CP; Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China.
  • Gao Y; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, P. R. China.
  • Zhou HH; Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, P. R. China.
  • Yin JY; Department of Cardiovascular, Central Hospital of Shaoyang, Shaoyang 422000, P. R. China.
Sci Data ; 5: 180284, 2018 12 11.
Article em En | MEDLINE | ID: mdl-30531820
ABSTRACT
Gene-gene (GXG) and gene-environment (GXE) interactions play important roles in pharmacogenetics study. Simultaneously incorporating multiple single nucleotide polymorphisms (SNPs) and clinical factors is needed to explore the association of their interactions with drug response and toxicity phenotypes. We genotyped 504 SNPs in a total of 490 Chinese non-small cell lung cancer (NSCLC) patients, and the correlation of GXG and GXE interactions with platinum-based chemotherapeutic efficacy and safety were analyzed. In this data descriptor, we shared our data set which could help others to reuse them. All kinds of file types needed for GXG and GXE analysis were supplied. The process of genotyping and data analysis was also introduced step by step.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Epistasia Genética / Interação Gene-Ambiente / Neoplasias Pulmonares Limite: Humans Idioma: En Revista: Sci Data Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Epistasia Genética / Interação Gene-Ambiente / Neoplasias Pulmonares Limite: Humans Idioma: En Revista: Sci Data Ano de publicação: 2018 Tipo de documento: Article