Initiation and Evolution of Early Onset Prostate Cancer.

Russo, Joshua W; Balk, Steven P

Russo, Joshua W; Balk, Steven P.

Afiliação

Russo JW; Hematology-Oncology Division, Department of Medicine and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Balk SP; Hematology-Oncology Division, Department of Medicine and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address: sbalk@bidmc.harvard.edu.

Cancer Cell ; 34(6): 874-876, 2018 12 10.

Article em En | MEDLINE | ID: mdl-30537509

ABSTRACT

ABSTRACT

In this issue of Cancer Cell, Gerhauser et al. analyze early-onset prostate cancers, showing roles for androgen receptor-driven rearrangements, an early APOBEC-driven mutational mechanism, and ESRP1 gene duplication. Through integration of whole-genome, transcriptome, and methylome data, they identify high-risk subgroups and develop an algorithm that may predict molecular evolution.

Assuntos

Neoplasias da Próstata; Receptores Androgênicos/genética; Evolução Molecular; Humanos; Masculino; Mutação; Transcriptoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Receptores Androgênicos Tipo de estudo: Prognostic_studies Limite: Humans / Male Idioma: En Revista: Cancer Cell Assunto da revista: NEOPLASIAS Ano de publicação: 2018 Tipo de documento: Article País de afiliação: Estados Unidos

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