Di-2-ethylhexylphthalate promotes thyroid cell proliferation and DNA damage through activating thyrotropin-receptor-mediated pathways in vitro and in vivo.

Kim, Seoyoung; Park, Ga-Young; Yoo, Young Jo; Jeong, Ji Seong; Nam, Ki Taek; Jee, Sun-Ha; Lim, Kyung-Min; Lee, Yun-Sil

Kim, Seoyoung; Park, Ga-Young; Yoo, Young Jo; Jeong, Ji Seong; Nam, Ki Taek; Jee, Sun-Ha; Lim, Kyung-Min; Lee, Yun-Sil.

Afiliação

Kim S; Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea.
Park GY; Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea.
Yoo YJ; Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea.
Jeong JS; Developmental and Reproductive Toxicology Research Group, Korea Institute of Toxicology, Daejeon, 34114, Republic of Korea.
Nam KT; Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
Jee SH; Department of Epidemiology and Health Promotion and Institute for Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, 03722, Republic of Korea.
Lim KM; Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea. Electronic address: kmlim@ewha.ac.kr.
Lee YS; Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 03760, Republic of Korea. Electronic address: yslee0425@ewha.ac.kr.

Food Chem Toxicol ; 124: 265-272, 2019 Feb.

Article em En | MEDLINE | ID: mdl-30543897

Assuntos

Proliferação de Células/efeitos dos fármacos; Dano ao DNA/efeitos dos fármacos; Dietilexilftalato/efeitos adversos; Receptores da Tireotropina/metabolismo; Transdução de Sinais/efeitos dos fármacos; Glândula Tireoide/efeitos dos fármacos; Animais; Linhagem Celular Tumoral; Feminino; Histonas/metabolismo; Humanos; Masculino; Fosfoproteínas/metabolismo; Ratos Sprague-Dawley; Glândula Tireoide/patologia

Palavras-chave

DNA damage; Di-(2-ethylhexyl) phthalate (DEHP); Phthalates; Proliferation; Thyroid; Thyrotropin receptor (TSH)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glândula Tireoide / Dano ao DNA / Receptores da Tireotropina / Transdução de Sinais / Proliferação de Células / Dietilexilftalato Limite: Animals / Female / Humans / Male Idioma: En Revista: Food Chem Toxicol Ano de publicação: 2019 Tipo de documento: Article País de publicação: Reino Unido

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