Two myeloid leukemia cases with rare FLT3 fusions.
Cold Spring Harb Mol Case Stud
; 4(6)2018 12.
Article
em En
| MEDLINE
| ID: mdl-30559310
ABSTRACT
Genetic rearrangements involving FLT3 are rare and only recently have been detected in myeloid/lymphoid neoplasms associated with eosinophilia (MLN-eos) and chronic myeloproliferative disorders. Here we report two cases with FLT3 fusions in patients demonstrating mixed features of myelodysplastic/myeloproliferative neoplasms. In the first case, FLT3 was fused with a new fusion partner MYO18A in a patient with marrow features most consistent with atypical chronic myeloid leukemia; the second case involving ETV6-FLT3 fusion was observed in a case with bone marrow features most consistent with chronic myelomonocytic leukemia. Notably, we observed that samples from both patients demonstrated FLT3 inhibitor (quizartinib and sorafenib) sensitivity in ex vivo drug screening assay.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia Mieloide
/
Tirosina Quinase 3 Semelhante a fms
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Doenças Mieloproliferativas-Mielodisplásicas
Limite:
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Cold Spring Harb Mol Case Stud
Ano de publicação:
2018
Tipo de documento:
Article
País de afiliação:
Estados Unidos