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Design, synthesis, in silico pharmacokinetics prediction and biological evaluation of 1,4-dihydroindeno[1,2-c]pyrazole chalcone as EGFR /Akt pathway inhibitors.
Khan, Irfan; Garikapati, Koteswara Rao; Setti, Aravind; Shaik, Anver Basha; Kanth Makani, Venkata Krishna; Shareef, Mohd Adil; Rajpurohit, Hemshikha; Vangara, Namratha; Pal-Bhadra, Manika; Kamal, Ahmed; Kumar, C Ganesh.
Afiliação
  • Khan I; Organic Synthesis and Process Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
  • Garikapati KR; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India; Applied Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
  • Setti A; Department of Genetics, Osmania University, Hyderabad 500007, India.
  • Shaik AB; Organic Synthesis and Process Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
  • Kanth Makani VK; Applied Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
  • Shareef MA; Organic Synthesis and Process Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
  • Rajpurohit H; Organic Synthesis and Process Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
  • Vangara N; Applied Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
  • Pal-Bhadra M; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India; Applied Biology Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India. Electronic address: manika@iict.res.in.
  • Kamal A; School of Pharmaceutical Education and Research, Jamia Hamdard University, New Delhi 110062, India. Electronic address: ahmedkamal915@gmail.com.
  • Kumar CG; Organic Synthesis and Process Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: cgkumar.iict@gov.in.
Eur J Med Chem ; 163: 636-648, 2019 Feb 01.
Article em En | MEDLINE | ID: mdl-30562699
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Chalconas / Proteína Oncogênica v-akt Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Índia País de publicação: França
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Chalconas / Proteína Oncogênica v-akt Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Eur J Med Chem Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Índia País de publicação: França