Preparation, chemical characterization and determination of crocetin's pharmacokinetics after oral and intravenous administration of saffron (Crocus sativus L.) aqueous extract to C57/BL6J mice.

Christodoulou, Eirini; Grafakou, Maria-Eleni; Skaltsa, Eleni; Kadoglou, Nikolaos; Kostomitsopoulos, Nikolaos; Valsami, Georgia

Christodoulou, Eirini; Grafakou, Maria-Eleni; Skaltsa, Eleni; Kadoglou, Nikolaos; Kostomitsopoulos, Nikolaos; Valsami, Georgia.

Afiliação

Christodoulou E; Laboratory of Biopharmaceutics and Pharmacokinetics, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.
Grafakou ME; Laboratory of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.
Skaltsa E; Laboratory of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.
Kadoglou N; Oxford University, Oxford, UK.
Kostomitsopoulos N; Center of Clinical Experimental Surgery and Translational Research, Biomedical Research Foundation, Academy of Athens, Athens, Greece.
Valsami G; Laboratory of Biopharmaceutics and Pharmacokinetics, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.

J Pharm Pharmacol ; 71(5): 753-764, 2019 May.

Article em En | MEDLINE | ID: mdl-30575029

Assuntos

Carotenoides/química; Carotenoides/farmacocinética; Administração Intravenosa; Administração Oral; Animais; Disponibilidade Biológica; Carotenoides/administração & dosagem; Carotenoides/sangue; Crocus/química; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Extratos Vegetais/administração & dosagem; Extratos Vegetais/química; Extratos Vegetais/farmacocinética; Distribuição Aleatória; Vitamina A/análogos & derivados

Palavras-chave

chemical profile; crocetin; extract; pharmacokinetics; saffron

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carotenoides Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Pharm Pharmacol Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Grécia País de publicação: Reino Unido

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google