An Intensive, Active Surveillance Reveals Continuous Invasion and High Diversity of Rhinovirus in Households.
J Infect Dis
; 219(7): 1049-1057, 2019 03 15.
Article
em En
| MEDLINE
| ID: mdl-30576538
ABSTRACT
We report on infection patterns in 5 households (78 participants) delineating the natural history of human rhinovirus (HRV). Nasopharyngeal collections were obtained every 3-4 days irrespective of symptoms, over a 6-month period, with molecular screening for HRV and typing by sequencing VP4/VP2 junction. Overall, 311/3468 (8.9%) collections were HRV positive 256 were classified into 3 species 104 (40.6%) HRV-A; 14 (5.5%) HRV-B, and 138 (53.9%) HRV-C. Twenty-six known HRV types (13 HRV-A, 3 HRV-B, and 10 HRV-C) were identified (A75, C1, and C35 being most frequent). We observed continuous invasion and temporal clustering of HRV types in households (range 5-13 over 6 months). Intrahousehold transmission was independent of clinical status but influenced by age. Most (89.0%) of HRV infection episodes were limited to <14 days. Individual repeat infections were frequent (range 1-7 over 6 months), decreasing with age, and almost invariably heterotypic, indicative of lasting type-specific immunity and low cross-type protection.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Rhinovirus
/
Nasofaringe
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Resfriado Comum
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Infecções por Picornaviridae
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Screening_studies
Limite:
Adolescent
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Adult
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Child
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Child, preschool
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Humans
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Infant
País/Região como assunto:
Africa
Idioma:
En
Revista:
J Infect Dis
Ano de publicação:
2019
Tipo de documento:
Article