Alogliptin prevents diastolic dysfunction and preserves left ventricular mitochondrial function in diabetic rabbits.

Zhang, Xiaowei; Zhang, Zhiwei; Yang, Yajuan; Suo, Ya; Liu, Ruimeng; Qiu, Jiuchun; Zhao, Yungang; Jiang, Ning; Liu, Changle; Tse, Gary; Li, Guangping; Liu, Tong

Zhang, Xiaowei; Zhang, Zhiwei; Yang, Yajuan; Suo, Ya; Liu, Ruimeng; Qiu, Jiuchun; Zhao, Yungang; Jiang, Ning; Liu, Changle; Tse, Gary; Li, Guangping; Liu, Tong.

Afiliação

Zhang X; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, No. 23 Pingjiang Road, Hexi District, Tianjin, 300211, People's Republic of China.
Zhang Z; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, No. 23 Pingjiang Road, Hexi District, Tianjin, 300211, People's Republic of China.
Yang Y; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, No. 23 Pingjiang Road, Hexi District, Tianjin, 300211, People's Republic of China.
Suo Y; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, No. 23 Pingjiang Road, Hexi District, Tianjin, 300211, People's Republic of China.
Liu R; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, No. 23 Pingjiang Road, Hexi District, Tianjin, 300211, People's Republic of China.
Qiu J; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, No. 23 Pingjiang Road, Hexi District, Tianjin, 300211, People's Republic of China.
Zhao Y; Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, Department of Health & Exercise Science, Tianjin University of Sport, Tianjin, 300381, People's Republic of China.
Jiang N; Tianjin Key Laboratory of Exercise Physiology and Sports Medicine, Department of Health & Exercise Science, Tianjin University of Sport, Tianjin, 300381, People's Republic of China.
Liu C; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, No. 23 Pingjiang Road, Hexi District, Tianjin, 300211, People's Republic of China.
Tse G; Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, SAR, China.
Li G; Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, SAR, China.
Liu T; Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, No. 23 Pingjiang Road, Hexi District, Tianjin, 300211, People's Republic of China. tjcardiol@126.com.

Cardiovasc Diabetol ; 17(1): 160, 2018 12 27.

Article em En | MEDLINE | ID: mdl-30591063

Assuntos

Diabetes Mellitus Experimental/tratamento farmacológico; Cardiomiopatias Diabéticas/prevenção & controle; Inibidores da Dipeptidil Peptidase IV/farmacologia; Mitocôndrias Cardíacas/efeitos dos fármacos; Piperidinas/farmacologia; Uracila/análogos & derivados; Disfunção Ventricular Esquerda/prevenção & controle; Função Ventricular Esquerda/efeitos dos fármacos; Animais; Diabetes Mellitus Experimental/complicações; Diabetes Mellitus Experimental/metabolismo; Cardiomiopatias Diabéticas/etiologia; Cardiomiopatias Diabéticas/metabolismo; Cardiomiopatias Diabéticas/fisiopatologia; Diástole/efeitos dos fármacos; Fibrose; Hipertrofia Ventricular Esquerda/etiologia; Hipertrofia Ventricular Esquerda/metabolismo; Hipertrofia Ventricular Esquerda/fisiopatologia; Hipertrofia Ventricular Esquerda/prevenção & controle; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Mitocôndrias Cardíacas/metabolismo; Mitocôndrias Cardíacas/patologia; Fator 1 Nuclear Respiratório/metabolismo; Estresse Oxidativo/efeitos dos fármacos; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/metabolismo; Coelhos; Espécies Reativas de Oxigênio/metabolismo; Transdução de Sinais/efeitos dos fármacos; Volume Sistólico/efeitos dos fármacos; Fatores de Transcrição/metabolismo; Uracila/farmacologia; Disfunção Ventricular Esquerda/etiologia; Disfunção Ventricular Esquerda/metabolismo; Disfunção Ventricular Esquerda/fisiopatologia; Pressão Ventricular/efeitos dos fármacos; Remodelação Ventricular/efeitos dos fármacos

Palavras-chave

Diabetes mellitus; Diabetic cardiomyopathy; Dipeptidyl peptidase-4 inhibitors; Mitochondrial biogenesis; Mitochondrial function

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Uracila / Função Ventricular Esquerda / Disfunção Ventricular Esquerda / Diabetes Mellitus Experimental / Inibidores da Dipeptidil Peptidase IV / Cardiomiopatias Diabéticas / Mitocôndrias Cardíacas Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Cardiovasc Diabetol Assunto da revista: ANGIOLOGIA / CARDIOLOGIA / ENDOCRINOLOGIA Ano de publicação: 2018 Tipo de documento: Article País de publicação: Reino Unido

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