Insulin resistance influences the impact of hypertension on left ventricular diastolic dysfunction in a community sample.
Clin Cardiol
; 42(2): 305-311, 2019 Feb.
Article
em En
| MEDLINE
| ID: mdl-30592058
ABSTRACT
BACKGROUND:
Although obesity-associated metabolic abnormalities (insulin resistance-IR) may not play as marked a role in determining left ventricular (LV) diastolic dysfunction (DD) as hypertension, the impact of combinations of these risk factors on DD is unknown.HYPOTHESIS:
We hypothesized that IR influences the impact of hypertension on DD.METHODS:
In 704 randomly selected participants from a community sample with a high prevalence of hypertension (50.6%) and obesity (46.5%), we determined adiposity indices, IR from the homeostasis model (HOMA-IR) and LV diastolic function using standard echocardiographic techniques.RESULTS:
HOMA-IR was independently associated with lateral wall e' and E/e' (P < 0.05 to P < 0.005) as well as a diagnosis of DD (P < 0.02). Importantly, however, an enhanced relationship between HOMA-IR and E/e' in hypertensives (n = 356, partial r = 0.15, P < 0.005) as compared to normotensives (n = 348, partial r = 0.02 P = 0.75) was noted. Consequently, as compared to normotensives, with adjustments for confounders, hypertension was independently associated with DD only in those with the highest tertile of HOMA-IR (odds ratio = 2.65, 95% confidence interval = 1.29-5.42, P < 0.01), while in those with the lowest tertile of HOMA-IR, hypertension failed to show a higher prevalence of DD (P = 0.22).CONCLUSIONS:
Insulin resistance enhances the impact of hypertension on LV DD. Thus, DD is more likely to occur with the combination of hypertension and IR.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pressão Sanguínea
/
Resistência à Insulina
/
Função Ventricular Esquerda
/
Disfunção Ventricular Esquerda
/
Adiposidade
/
Hipertensão
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Clin Cardiol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
África do Sul