Precuneus and psychiatric manifestations: Novel neurobiological formulations through lesion based connectivity mapping of psychopathology.
Asian J Psychiatr
; 39: 98-100, 2019 Jan.
Article
em En
| MEDLINE
| ID: mdl-30599452
ABSTRACT
Lesion-based investigations of psychopathology have preceded contemporary network-neuroscience initiatives. However, brain-lesions detected in routine psychiatric practice are often considered incidental and therefore ignored. Here, we illustrate a strategy to combine individual subject-level lesion information with open-source normative functional-connectomics data to make putative, neuroscience-informed symptom interpretation. Specifically, we report a patient with left precuneus granulomatous lesion and seizures followed by two distinct symptoms - kinetopsia and delusions of nihilism and guilt - which had a differential treatment response. The lesion-based brain-mapping approach could identify correlated (default-mode) and anti-correlated (temporo-parieto-occipital) networks, which enabled a neurobiological formulation of these diverse clinical manifestations.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Lobo Parietal
/
Esquizofrenia Paranoide
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Neoplasias Encefálicas
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Imageamento por Ressonância Magnética
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Transtorno Depressivo Maior
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Granuloma
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Female
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Humans
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Middle aged
Idioma:
En
Revista:
Asian J Psychiatr
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Índia