Caspase 3/ROCK1 pathway mediates high glucose-induced platelet microparticles shedding.

Wang, Gui Hua; Ma, Kun Ling; Zhang, Yang; Hu, Ze Bo; Liu, Liang; Lu, Jian; Chen, Pei Pei; Lu, Chen Chen; Ruan, Xiong Zhong; Liu, Bi Cheng

Wang, Gui Hua; Ma, Kun Ling; Zhang, Yang; Hu, Ze Bo; Liu, Liang; Lu, Jian; Chen, Pei Pei; Lu, Chen Chen; Ruan, Xiong Zhong; Liu, Bi Cheng.

Afiliação

Wang GH; Institute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Ma KL; Institute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China. Electronic address: klma05@163.com.
Zhang Y; Institute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Hu ZB; Institute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Liu L; Institute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Lu J; Institute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Chen PP; Institute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Lu CC; Institute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.
Ruan XZ; Centre for Nephrology, University College London (UCL) Medical School, Royal Free Campus, UK.
Liu BC; Institute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.

Biochem Biophys Res Commun ; 509(2): 596-602, 2019 02 05.

Article em En | MEDLINE | ID: mdl-30606480

Assuntos

Plaquetas/metabolismo; Caspase 3/metabolismo; Micropartículas Derivadas de Células/metabolismo; Glucose/metabolismo; Transdução de Sinais; Quinases Associadas a rho/metabolismo; Animais; Hiperglicemia/metabolismo; Masculino; Ratos Sprague-Dawley

Palavras-chave

High glucose; Platelet microparticles; Rho-associated kinase 1; caspase3

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Plaquetas / Transdução de Sinais / Caspase 3 / Quinases Associadas a rho / Micropartículas Derivadas de Células / Glucose Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

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