Conventionally fractionated stereotactic radiotherapy (CFRT) in combination with dose-dense temozolomide (TMZ) in relapsed malignant glioma: A case report.
Medicine (Baltimore)
; 98(1): e13869, 2019 Jan.
Article
em En
| MEDLINE
| ID: mdl-30608405
ABSTRACT
RATIONALE At present, there is no uniform consensus on the treatment of recurrent glioblastoma, especially the re-irradiation dose and temozolomide (TMZ) dose. The literature on the treatment of recurrent glioblastoma (GBM) by conventionally fractionated stereotactic radiotherapy (CFRT) is even rarer. PATIENT CONCERNS A 44-year-old woman was admitted to our hospital for residual tumor after reoperation. DIAGNOSES Postoperative pathological diagnosis was GBM, WHO grade IV. The brain magnetic resonance imaging re-examination showed abnormal enhancement around the local operative region after resection of the left frontal lobe tumor, and there was presence of residual tumor. INTERVENTIONS:
The patient was treated with reoperation followed by re-irradiation plus dose-dense TMZ to achieve complete remission.OUTCOMES:
Complete remission was observed at the end of radiotherapy and at the 1 month follow-up after radiotherapy. LESSONS This study suggests that CFRT plus dose-dense TMZ might be a feasible option for the treatment in relapsed malignant glioma patients with good general condition.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
/
Radiocirurgia
/
Glioblastoma
/
Antineoplásicos Alquilantes
/
Temozolomida
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Medicine (Baltimore)
Ano de publicação:
2019
Tipo de documento:
Article