X-Chromosome Dosage Modulates Multiple Molecular and Cellular Properties of Mouse Pluripotent Stem Cells Independently of Global DNA Methylation Levels.

Song, Juan; Janiszewski, Adrian; De Geest, Natalie; Vanheer, Lotte; Talon, Irene; El Bakkali, Mouna; Oh, Taeho; Pasque, Vincent

Song, Juan; Janiszewski, Adrian; De Geest, Natalie; Vanheer, Lotte; Talon, Irene; El Bakkali, Mouna; Oh, Taeho; Pasque, Vincent.

Afiliação

Song J; KU Leuven - University of Leuven, Department of Development and Regeneration, Leuven Stem Cell Institute, Leuven Cancer Institute, Herestraat 49, 3000 Leuven, Belgium. Electronic address: juan.song@kuleuven.be.
Janiszewski A; KU Leuven - University of Leuven, Department of Development and Regeneration, Leuven Stem Cell Institute, Leuven Cancer Institute, Herestraat 49, 3000 Leuven, Belgium.
De Geest N; KU Leuven - University of Leuven, Department of Development and Regeneration, Leuven Stem Cell Institute, Leuven Cancer Institute, Herestraat 49, 3000 Leuven, Belgium.
Vanheer L; KU Leuven - University of Leuven, Department of Development and Regeneration, Leuven Stem Cell Institute, Leuven Cancer Institute, Herestraat 49, 3000 Leuven, Belgium.
Talon I; KU Leuven - University of Leuven, Department of Development and Regeneration, Leuven Stem Cell Institute, Leuven Cancer Institute, Herestraat 49, 3000 Leuven, Belgium.
El Bakkali M; KU Leuven - University of Leuven, Department of Development and Regeneration, Leuven Stem Cell Institute, Leuven Cancer Institute, Herestraat 49, 3000 Leuven, Belgium.
Oh T; KU Leuven - University of Leuven, Department of Development and Regeneration, Leuven Stem Cell Institute, Leuven Cancer Institute, Herestraat 49, 3000 Leuven, Belgium.
Pasque V; KU Leuven - University of Leuven, Department of Development and Regeneration, Leuven Stem Cell Institute, Leuven Cancer Institute, Herestraat 49, 3000 Leuven, Belgium. Electronic address: vincent.pasque@kuleuven.be.

Stem Cell Reports ; 12(2): 333-350, 2019 02 12.

Article em En | MEDLINE | ID: mdl-30639215

Assuntos

Metilação de DNA/genética; Dosagem de Genes/genética; Células-Tronco Pluripotentes/fisiologia; Cromossomo X/genética; Animais; Linhagem Celular; Reprogramação Celular/genética; Cromatina/genética; Fosfatases de Especificidade Dupla/genética; Epigênese Genética/genética; Epigenômica/métodos; Feminino; Células-Tronco Pluripotentes Induzidas/fisiologia; Masculino; Camundongos; Fosfatases da Proteína Quinase Ativada por Mitógeno/genética; Transcriptoma/genética

Palavras-chave

DNA methylation; X dosage; X-chromosome inactivation; X-chromosome reactivation; chromatin accessibility; dosage compensation; iPS cells; mouse pluripotent stem cells; pluripotency

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromossomo X / Dosagem de Genes / Metilação de DNA / Células-Tronco Pluripotentes Limite: Animals Idioma: En Revista: Stem Cell Reports Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos

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