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Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation.
Kano, Yoshihito; Gebregiworgis, Teklab; Marshall, Christopher B; Radulovich, Nikolina; Poon, Betty P K; St-Germain, Jonathan; Cook, Jonathan D; Valencia-Sama, Ivette; Grant, Benjamin M M; Herrera, Silvia Gabriela; Miao, Jinmin; Raught, Brian; Irwin, Meredith S; Lee, Jeffrey E; Yeh, Jen Jen; Zhang, Zhong-Yin; Tsao, Ming-Sound; Ikura, Mitsuhiko; Ohh, Michael.
Afiliação
  • Kano Y; Department of Laboratory Medicine and Pathobiology, University of Toronto, 661 University Avenue, Toronto, ON, M5G 1M1, Canada.
  • Gebregiworgis T; Department of Biochemistry, University of Toronto, 661 University Avenue, Toronto, ON, M5G 1M1, Canada.
  • Marshall CB; Princess Margaret Cancer Centre, University Health Network and Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, ON, M5G 1L7, Canada.
  • Radulovich N; Princess Margaret Cancer Centre, University Health Network and Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, ON, M5G 1L7, Canada.
  • Poon BPK; Princess Margaret Cancer Centre, University Health Network and Department of Pathology, University of Toronto, Toronto, ON, M5G 1L7, Canada.
  • St-Germain J; Department of Laboratory Medicine and Pathobiology, University of Toronto, 661 University Avenue, Toronto, ON, M5G 1M1, Canada.
  • Cook JD; Princess Margaret Cancer Centre, University Health Network and Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, ON, M5G 1L7, Canada.
  • Valencia-Sama I; Department of Laboratory Medicine and Pathobiology, University of Toronto, 661 University Avenue, Toronto, ON, M5G 1M1, Canada.
  • Grant BMM; Department of Laboratory Medicine and Pathobiology, University of Toronto, 661 University Avenue, Toronto, ON, M5G 1M1, Canada.
  • Herrera SG; Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Toronto, ON, 5G OA4, Canada.
  • Miao J; Princess Margaret Cancer Centre, University Health Network and Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, ON, M5G 1L7, Canada.
  • Raught B; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599, USA.
  • Irwin MS; Department of Medicinal Chemistry and Molecular Pharmacology, Center for Cancer Research and Institute for Drug Discovery, Purdue University, 720 Clinic Drive, West Lafayette, IN, 47907, USA.
  • Lee JE; Princess Margaret Cancer Centre, University Health Network and Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, ON, M5G 1L7, Canada.
  • Yeh JJ; Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, 686 Bay Street, Toronto, ON, 5G OA4, Canada.
  • Zhang ZY; Department of Laboratory Medicine and Pathobiology, University of Toronto, 661 University Avenue, Toronto, ON, M5G 1M1, Canada.
  • Tsao MS; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599, USA.
  • Ikura M; Department of Surgery, University of North Carolina, Chapel Hill, NC, 27599, USA.
  • Ohh M; Department of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599, USA.
Nat Commun ; 10(1): 224, 2019 01 15.
Article em En | MEDLINE | ID: mdl-30644389
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas p21(ras) / Proteína Tirosina Fosfatase não Receptora Tipo 11 / GTP Fosfo-Hidrolases / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Canadá País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas p21(ras) / Proteína Tirosina Fosfatase não Receptora Tipo 11 / GTP Fosfo-Hidrolases / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Canadá País de publicação: Reino Unido