YAP1/Twist promotes fibroblast activation and lung fibrosis that conferred by miR-15a loss in IPF.

Chen, Yingzhun; Zhao, Xiaoguang; Sun, Jian; Su, Wei; Zhang, Lu; Li, Yingnan; Liu, Yingqi; Zhang, Lijia; Lu, Yanjie; Shan, Hongli; Liang, Haihai

Chen, Yingzhun; Zhao, Xiaoguang; Sun, Jian; Su, Wei; Zhang, Lu; Li, Yingnan; Liu, Yingqi; Zhang, Lijia; Lu, Yanjie; Shan, Hongli; Liang, Haihai.

Afiliação

Chen Y; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, People's Republic of China.
Zhao X; Department of Pathology, the 2nd Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang, People's Republic of China.
Sun J; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, People's Republic of China.
Su W; Northern Translational Medicine Research and Cooperation Center, Heilongjiang Academy of Medical Sciences, Harbin Medical University, Harbin, Heilongjiang, 150081, People's Republic of China.
Zhang L; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, People's Republic of China.
Li Y; Northern Translational Medicine Research and Cooperation Center, Heilongjiang Academy of Medical Sciences, Harbin Medical University, Harbin, Heilongjiang, 150081, People's Republic of China.
Liu Y; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, People's Republic of China.
Zhang L; Northern Translational Medicine Research and Cooperation Center, Heilongjiang Academy of Medical Sciences, Harbin Medical University, Harbin, Heilongjiang, 150081, People's Republic of China.
Lu Y; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, People's Republic of China.
Shan H; Northern Translational Medicine Research and Cooperation Center, Heilongjiang Academy of Medical Sciences, Harbin Medical University, Harbin, Heilongjiang, 150081, People's Republic of China.
Liang H; Department of Pharmacology (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, 150081, People's Republic of China.

Cell Death Differ ; 26(9): 1832-1844, 2019 09.

Article em En | MEDLINE | ID: mdl-30644438

Assuntos

Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Proteínas de Ciclo Celular/metabolismo; Fibrose Pulmonar Idiopática/metabolismo; MicroRNAs/metabolismo; Fatores de Transcrição/metabolismo; Proteína 1 Relacionada a Twist/metabolismo; Proteínas Adaptadoras de Transdução de Sinal/genética; Animais; Bleomicina/toxicidade; Proteínas de Ciclo Celular/genética; Diferenciação Celular/genética; Proliferação de Células/genética; Bases de Dados de Ácidos Nucleicos; Modelos Animais de Doenças; Matriz Extracelular/metabolismo; Fibroblastos/efeitos dos fármacos; Fibroblastos/metabolismo; Fibrose; Humanos; Fibrose Pulmonar Idiopática/induzido quimicamente; Fibrose Pulmonar Idiopática/genética; Pulmão/metabolismo; Pulmão/patologia; Camundongos; Camundongos Endogâmicos C57BL; MicroRNAs/genética; RNA Interferente Pequeno; Transdução de Sinais/genética; Fatores de Transcrição/genética; Fator de Crescimento Transformador beta1/metabolismo; Proteína 1 Relacionada a Twist/genética; Proteínas de Sinalização YAP

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Proteínas de Ciclo Celular / MicroRNAs / Proteínas Adaptadoras de Transdução de Sinal / Proteína 1 Relacionada a Twist / Fibrose Pulmonar Idiopática Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cell Death Differ Ano de publicação: 2019 Tipo de documento: Article País de publicação: Reino Unido

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