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The OMERACT-OARSI Core Domain Set for Measurement in Clinical Trials of Hip and/or Knee Osteoarthritis.
Smith, Toby O; Hawker, Gillian A; Hunter, David J; March, Lyn M; Boers, Maarten; Shea, Beverley J; Christensen, Robin; Guillemin, Francis; Terwee, Caroline B; Williamson, Paula R; Dodd, Susanna; Roos, Ewa M; Loeser, Richard F; Schnitzer, Thomas J; Kloppenburg, Margreet; Neogi, Tuhina; Ladel, Christoph H; Kalsi, Gurdyal; Kaiser, Ulrike; Buttel, Thomas W; Ashford, Anne E; Mobasheri, Ali; Arden, Nigel K; Tennant, Alan; Hochberg, Marc C; de Wit, Maarten; Tugwell, Peter; Conaghan, Philip G.
Afiliação
  • Smith TO; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and UK National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford; Institute of Translational Medicine, University of Liverpool, Liverp
  • Hawker GA; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of
  • Hunter DJ; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and UK National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford; Institute of Translational Medicine, University of Liverpool, Liverp
  • March LM; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of
  • Boers M; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and UK National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford; Institute of Translational Medicine, University of Liverpool, Liverp
  • Shea BJ; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of
  • Christensen R; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and UK National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford; Institute of Translational Medicine, University of Liverpool, Liverp
  • Guillemin F; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of
  • Terwee CB; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and UK National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford; Institute of Translational Medicine, University of Liverpool, Liverp
  • Williamson PR; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of
  • Dodd S; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and UK National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford; Institute of Translational Medicine, University of Liverpool, Liverp
  • Roos EM; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of
  • Loeser RF; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and UK National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford; Institute of Translational Medicine, University of Liverpool, Liverp
  • Schnitzer TJ; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of
  • Kloppenburg M; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and UK National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford; Institute of Translational Medicine, University of Liverpool, Liverp
  • Neogi T; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of
  • Ladel CH; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and UK National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford; Institute of Translational Medicine, University of Liverpool, Liverp
  • Kalsi G; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of
  • Kaiser U; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and UK National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford; Institute of Translational Medicine, University of Liverpool, Liverp
  • Buttel TW; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of
  • Ashford AE; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and UK National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford; Institute of Translational Medicine, University of Liverpool, Liverp
  • Mobasheri A; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of
  • Arden NK; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and UK National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford; Institute of Translational Medicine, University of Liverpool, Liverp
  • Tennant A; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of
  • Hochberg MC; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and UK National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford; Institute of Translational Medicine, University of Liverpool, Liverp
  • de Wit M; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of
  • Tugwell P; From the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and UK National Institute for Health Research (NIHR) Oxford Biomedical Research Centre, John Radcliffe Hospital, Oxford; Institute of Translational Medicine, University of Liverpool, Liverp
  • Conaghan PG; T.O. Smith, PhD, Senior Researcher in Rehabilitation, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, and NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital; G.A. Hawker, PhD, Professor of Medicine, Department of Medicine, Faculty of
J Rheumatol ; 46(8): 981-989, 2019 08.
Article em En | MEDLINE | ID: mdl-30647185
ABSTRACT

OBJECTIVE:

To update the 1997 OMERACT-OARSI (Outcome Measures in Rheumatology-Osteoarthritis Research Society International) core domain set for clinical trials in hip and/or knee osteoarthritis (OA).

METHODS:

An initial review of the COMET database of core outcome sets (COS) was undertaken to identify all domains reported in previous COS including individuals with hip and/or knee OA. These were presented during 5 patient and health professionals/researcher meetings in 3 continents (Europe, Australasia, North America). A 3-round international Delphi survey was then undertaken among patients, healthcare professionals, researchers, and industry representatives to gain consensus on key domains to be included in a core domain set for hip and/or knee OA. Findings were presented and discussed in small groups at OMERACT 2018, where consensus was obtained in the final plenary.

RESULTS:

Four previous COS were identified. Using these, and the patient and health professionals/researcher meetings, 50 potential domains formed the Delphi survey. There were 426 individuals from 25 different countries who contributed to the Delphi exercise. OMERACT 2018 delegates (n = 129) voted on candidate domains. Six domains gained agreement as mandatory to be measured and reported in all hip and/or knee OA clinical trials pain, physical function, quality of life, and patient's global assessment of the target joint, in addition to the mandated core domain of adverse events including mortality. Joint structure was agreed as mandatory in specific circumstances, i.e., depending on the intervention.

CONCLUSION:

The updated core domain set for hip and/or knee OA has been agreed upon. Work will commence to determine which outcome measurement instrument should be recommended to cover each core domain.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite do Quadril / Avaliação de Resultados em Cuidados de Saúde / Osteoartrite do Joelho Tipo de estudo: Guideline / Prognostic_studies Aspecto: Patient_preference Limite: Humans Idioma: En Revista: J Rheumatol Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteoartrite do Quadril / Avaliação de Resultados em Cuidados de Saúde / Osteoartrite do Joelho Tipo de estudo: Guideline / Prognostic_studies Aspecto: Patient_preference Limite: Humans Idioma: En Revista: J Rheumatol Ano de publicação: 2019 Tipo de documento: Article