Eye Complications During Dupilumab Treatment for Severe Atopic Dermatitis.
Acta Derm Venereol
; 99(4): 375-378, 2019 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-30653240
ABSTRACT
Dupilumab, the first biologic approved for treatment of atopic dermatitis, has demonstrated significant clinical effect and quality of life-enhancing capacity in clinical trials. In these, dupilumab-associated conjunctivitis where reported in a minority of patients. The present case series describe 10 patients treated with dupilumab where eye complications were very common. We have described patient characteristics, including FLG mutations, atopic history and clinical effect of dupilumab. Nine of 10 developed eye-complications, most commonly conjunctivitis (in 7/10). Other adverse events were herpes simplex virus uveitis and varicella-zoster virus meningitis. Although our case series is small, we conclude that dupilumab is an effective treatment option in severe atopic dermatitis, but that the risk of adverse events from the eyes and recurrence of herpes virus infections should be kept in mind. Close collaboration with an ophthalmologist is recommended, especially among patients with severe, long-lasting atopic dermatitis and/or previous eye disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
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Conjuntivite
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Dermatite Atópica
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Anticorpos Monoclonais
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Risk_factors_studies
Aspecto:
Patient_preference
Idioma:
En
Revista:
Acta Derm Venereol
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Suécia
País de publicação:
SE
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SUECIA
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SUÉCIA
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SWEDEN