Gambogenic acid triggers apoptosis in human nasopharyngeal carcinoma CNE-2Z cells by activating volume-sensitive outwardly rectifying chloride channel.

Su, Jingjing; Xu, Ting; Jiang, Genling; Hou, Mei; Liang, Mengru; Cheng, Hui; Li, Qinglin

Su, Jingjing; Xu, Ting; Jiang, Genling; Hou, Mei; Liang, Mengru; Cheng, Hui; Li, Qinglin.

Afiliação

Su J; Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui Province Key Laboratory of R&D of Traditional Chinese Medicine, Anhui University of Chinese Medicine, Hefei 230038, China.
Xu T; Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui Province Key Laboratory of R&D of Traditional Chinese Medicine, Anhui University of Chinese Medicine, Hefei 230038, China.
Jiang G; Anhui New Star Pharmaceutical Development Co., Ltd, Hefei 230038, China.
Hou M; Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui Province Key Laboratory of R&D of Traditional Chinese Medicine, Anhui University of Chinese Medicine, Hefei 230038, China.
Liang M; Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui Province Key Laboratory of R&D of Traditional Chinese Medicine, Anhui University of Chinese Medicine, Hefei 230038, China.
Cheng H; Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui Province Key Laboratory of R&D of Traditional Chinese Medicine, Anhui University of Chinese Medicine, Hefei 230038, China.
Li Q; Key Laboratory of Xin'an Medicine, Ministry of Education, Anhui Province Key Laboratory of R&D of Traditional Chinese Medicine, Anhui University of Chinese Medicine, Hefei 230038, China. Electronic address: liqinglin@ahtcm.edu.cn.

Fitoterapia ; 133: 150-158, 2019 Mar.

Article em En | MEDLINE | ID: mdl-30654125

Assuntos

Apoptose/efeitos dos fármacos; Canais de Cloreto/metabolismo; Carcinoma Nasofaríngeo/metabolismo; Neoplasias Nasofaríngeas/metabolismo; Xantenos/farmacologia; Fator 4 Ativador da Transcrição/metabolismo; Linhagem Celular Tumoral; Cloretos/análise; Chaperona BiP do Retículo Endoplasmático; Estresse do Retículo Endoplasmático; Garcinia/química; Proteínas de Choque Térmico/metabolismo; Humanos; Carcinoma Nasofaríngeo/tratamento farmacológico; Neoplasias Nasofaríngeas/tratamento farmacológico; Fator de Transcrição CHOP/metabolismo

Palavras-chave

Apoptosis; CNE-2Z cells; Gambogenic acid; Volume-sensitive outwardly rectifying chloride

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Xantenos / Neoplasias Nasofaríngeas / Apoptose / Canais de Cloreto / Carcinoma Nasofaríngeo Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Fitoterapia Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Holanda

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