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Altered Uncinate Fasciculus Microstructure in Childhood Anxiety Disorders in Boys But Not Girls.
Tromp, Do P M; Williams, Lisa E; Fox, Andrew S; Oler, Jonathan A; Roseboom, Patrick H; Rogers, Gregory M; Benson, Brenda E; Alexander, Andrew L; Pine, Daniel S; Kalin, Ned H.
Afiliação
  • Tromp DPM; The Department of Psychiatry (Tromp, Williams, Oler, Roseboom, Rogers, Alexander, Kalin), the Neuroscience Training Program (Tromp, Kalin), the Department of Medical Physics (Alexander), and the HealthEmotions Research Institute (Tromp, Williams, Oler, Roseboom, Kalin), University of Wisconsin, Madi
  • Williams LE; The Department of Psychiatry (Tromp, Williams, Oler, Roseboom, Rogers, Alexander, Kalin), the Neuroscience Training Program (Tromp, Kalin), the Department of Medical Physics (Alexander), and the HealthEmotions Research Institute (Tromp, Williams, Oler, Roseboom, Kalin), University of Wisconsin, Madi
  • Fox AS; The Department of Psychiatry (Tromp, Williams, Oler, Roseboom, Rogers, Alexander, Kalin), the Neuroscience Training Program (Tromp, Kalin), the Department of Medical Physics (Alexander), and the HealthEmotions Research Institute (Tromp, Williams, Oler, Roseboom, Kalin), University of Wisconsin, Madi
  • Oler JA; The Department of Psychiatry (Tromp, Williams, Oler, Roseboom, Rogers, Alexander, Kalin), the Neuroscience Training Program (Tromp, Kalin), the Department of Medical Physics (Alexander), and the HealthEmotions Research Institute (Tromp, Williams, Oler, Roseboom, Kalin), University of Wisconsin, Madi
  • Roseboom PH; The Department of Psychiatry (Tromp, Williams, Oler, Roseboom, Rogers, Alexander, Kalin), the Neuroscience Training Program (Tromp, Kalin), the Department of Medical Physics (Alexander), and the HealthEmotions Research Institute (Tromp, Williams, Oler, Roseboom, Kalin), University of Wisconsin, Madi
  • Rogers GM; The Department of Psychiatry (Tromp, Williams, Oler, Roseboom, Rogers, Alexander, Kalin), the Neuroscience Training Program (Tromp, Kalin), the Department of Medical Physics (Alexander), and the HealthEmotions Research Institute (Tromp, Williams, Oler, Roseboom, Kalin), University of Wisconsin, Madi
  • Benson BE; The Department of Psychiatry (Tromp, Williams, Oler, Roseboom, Rogers, Alexander, Kalin), the Neuroscience Training Program (Tromp, Kalin), the Department of Medical Physics (Alexander), and the HealthEmotions Research Institute (Tromp, Williams, Oler, Roseboom, Kalin), University of Wisconsin, Madi
  • Alexander AL; The Department of Psychiatry (Tromp, Williams, Oler, Roseboom, Rogers, Alexander, Kalin), the Neuroscience Training Program (Tromp, Kalin), the Department of Medical Physics (Alexander), and the HealthEmotions Research Institute (Tromp, Williams, Oler, Roseboom, Kalin), University of Wisconsin, Madi
  • Pine DS; The Department of Psychiatry (Tromp, Williams, Oler, Roseboom, Rogers, Alexander, Kalin), the Neuroscience Training Program (Tromp, Kalin), the Department of Medical Physics (Alexander), and the HealthEmotions Research Institute (Tromp, Williams, Oler, Roseboom, Kalin), University of Wisconsin, Madi
  • Kalin NH; The Department of Psychiatry (Tromp, Williams, Oler, Roseboom, Rogers, Alexander, Kalin), the Neuroscience Training Program (Tromp, Kalin), the Department of Medical Physics (Alexander), and the HealthEmotions Research Institute (Tromp, Williams, Oler, Roseboom, Kalin), University of Wisconsin, Madi
Am J Psychiatry ; 176(3): 208-216, 2019 03 01.
Article em En | MEDLINE | ID: mdl-30654645
ABSTRACT

OBJECTIVE:

Anxiety disorders are common, can result in lifelong suffering, and frequently begin before adolescence. Evidence from adults suggests that altered prefrontal-limbic connectivity is a pathophysiological feature of anxiety disorders. More specifically, in adults with anxiety disorders, decreased fractional anisotropy (FA), a measure of white matter integrity, has been observed in the uncinate fasciculus, the major tract that connects limbic and prefrontal regions. Because of the early onset of anxiety disorders and the increased incidence in anxiety disorders in females during their reproductive years, it is important to understand whether the reduction in uncinate fasciculus FA exists in children with anxiety disorders and the extent to which this alteration is sex related. To address these issues, the authors assessed FA in the uncinate fasciculus in unmedicated boys and girls with anxiety disorders.

METHODS:

FA measures were derived from diffusion tensor images that were acquired from 98 unmedicated children (ages 8-12); 52 met criteria for generalized anxiety disorder, separation anxiety disorder, social anxiety disorder, or anxiety disorder not otherwise specified, and 46 were matched control subjects.

RESULTS:

Tract-based results demonstrated that children with anxiety disorders have significant reductions in uncinate fasciculus FA. A significant sex-by-group interaction and post hoc testing revealed that this effect was evident only in boys. No other main effects or sex-by-group interactions were found for other white matter tracts.

CONCLUSIONS:

These findings provide evidence of uncinate fasciculus white matter alterations in boys with anxiety disorders. The data demonstrate that anxiety disorder-related alterations in prefrontal-limbic structural connectivity are present early in life, are not related to psychotropic medication exposure, and are sex specific. Building on these findings, future research has the potential to provide insights into the genesis and sexual dimorphism of the pathophysiology that leads to anxiety disorders, as well as to identify sex-specific early-life treatment targets.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Córtex Pré-Frontal / Lobo Frontal / Vias Neurais Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Female / Humans / Male Idioma: En Revista: Am J Psychiatry Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Córtex Pré-Frontal / Lobo Frontal / Vias Neurais Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Female / Humans / Male Idioma: En Revista: Am J Psychiatry Ano de publicação: 2019 Tipo de documento: Article