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Novel Cucurbitane Triterpenes from the Tubers of Hemsleya amabilis with Their Cytotoxic Acitivity.
Feng, Wei; Zhou, Yuan; Zhou, Ling-Yu; Kang, Li-Ying; Wang, Xiang; Li, Bao-Lin; Li, Qing; Niu, Li-Ying.
Afiliação
  • Feng W; School of Pharmaceutical Sciences, Hebei TCM Formula Granule Technology Innovation Center& TCM Formula Granule Research Center of Hebei Province University, Hebei University of Chinese Medicine, Shijiazhuang 050091, China. weifeng@hebcm.edu.cn.
  • Zhou Y; School of Pharmaceutical Sciences, Hebei TCM Formula Granule Technology Innovation Center& TCM Formula Granule Research Center of Hebei Province University, Hebei University of Chinese Medicine, Shijiazhuang 050091, China. 18832160770@163.com.
  • Zhou LY; School of Pharmaceutical Sciences, Hebei TCM Formula Granule Technology Innovation Center& TCM Formula Granule Research Center of Hebei Province University, Hebei University of Chinese Medicine, Shijiazhuang 050091, China. zhuangxzz@163.com.
  • Kang LY; School of Pharmaceutical Sciences, Hebei TCM Formula Granule Technology Innovation Center& TCM Formula Granule Research Center of Hebei Province University, Hebei University of Chinese Medicine, Shijiazhuang 050091, China. 13171895576@126.com.
  • Wang X; School of Pharmaceutical Sciences, Hebei TCM Formula Granule Technology Innovation Center& TCM Formula Granule Research Center of Hebei Province University, Hebei University of Chinese Medicine, Shijiazhuang 050091, China. wangxiangdea@126.com.
  • Li BL; School of Pharmaceutical Sciences, Hebei TCM Formula Granule Technology Innovation Center& TCM Formula Granule Research Center of Hebei Province University, Hebei University of Chinese Medicine, Shijiazhuang 050091, China. libaol2016@163.com.
  • Li Q; School of Pharmaceutical Sciences, Hebei TCM Formula Granule Technology Innovation Center& TCM Formula Granule Research Center of Hebei Province University, Hebei University of Chinese Medicine, Shijiazhuang 050091, China. lqlqlqlqlq5@126.com.
  • Niu LY; School of Pharmaceutical Sciences, Hebei TCM Formula Granule Technology Innovation Center& TCM Formula Granule Research Center of Hebei Province University, Hebei University of Chinese Medicine, Shijiazhuang 050091, China. niuliyingyy@126.com.
Molecules ; 24(2)2019 Jan 17.
Article em En | MEDLINE | ID: mdl-30658485
ABSTRACT
Chemical research of the medicinal plant Hemsleya amabilis (Cucurbitaceae) yielded five new cucurbitane-type triterpenes hemslelis A⁻E (1⁻5) by silica gel column, ODS column, and semi-HPLC techniques. Their structures were determined by spectroscopic analysis and examined alongside existing data from prior studies. Compounds 1⁻5 were evaluated for their cytotoxic activities against three human tumor cell lines, Hela, HCT-8, and HepG-2, with the IC50 ranging from 5.9 to 33.9 µM compared to Cisplatin.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Cucurbitaceae / Tubérculos / Glicosídeos Limite: Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Triterpenos / Cucurbitaceae / Tubérculos / Glicosídeos Limite: Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China