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Genetics, Cell Biology, and Pathophysiology of Pancreatitis.
Mayerle, Julia; Sendler, Matthias; Hegyi, Eszter; Beyer, Georg; Lerch, Markus M; Sahin-Tóth, Miklós.
Afiliação
  • Mayerle J; Medical Department II, University Hospital, LMU, Munich, Germany; Department of Medicine A, University Medicine Greifswald, Greifswald, Germany.
  • Sendler M; Department of Medicine A, University Medicine Greifswald, Greifswald, Germany.
  • Hegyi E; Institute for Translational Medicine, University of Pécs, Pécs, Hungary.
  • Beyer G; Medical Department II, University Hospital, LMU, Munich, Germany.
  • Lerch MM; Department of Medicine A, University Medicine Greifswald, Greifswald, Germany. Electronic address: lerch@uni-greifswald.de.
  • Sahin-Tóth M; Center for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University Henry M. Goldman School of Dental Medicine, Boston, Massachusetts.
Gastroenterology ; 156(7): 1951-1968.e1, 2019 05.
Article em En | MEDLINE | ID: mdl-30660731
Since the discovery of the first trypsinogen mutation in families with hereditary pancreatitis, pancreatic genetics has made rapid progress. The identification of mutations in genes involved in the digestive protease-antiprotease pathway has lent additional support to the notion that pancreatitis is a disease of autodigestion. Clinical and experimental observations have provided compelling evidence that premature intrapancreatic activation of digestive proteases is critical in pancreatitis onset. However, disease course and severity are mostly governed by inflammatory cells that drive local and systemic immune responses. In this article, we review the genetics, cell biology, and immunology of pancreatitis with a focus on protease activation pathways and other early events.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pâncreas / Pancreatite Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Gastroenterology Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pâncreas / Pancreatite Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Gastroenterology Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Estados Unidos