Potential therapeutic effect of curcumin, a natural mTOR inhibitor, in tuberous sclerosis complex.
Phytomedicine
; 54: 132-139, 2019 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-30668362
ABSTRACT
BACKGROUND:
Curcumin is a polyphenol natural product of the plant Curcuma longa. Recent studies suggest that curcumin inhibit mTOR activity in vitro, which prompts us to investigate curcumin function as a new class of mTOR inhibitor suitable for tuberous sclerosis complex (TSC) treatment.PURPOSE:
We aim to investigate the efficacy of curcumin in the treatment of TSC related manifestations in animal model. STUDYDESIGN:
Solid lipid curcumin particle (SLCP), a novel curcumin formulation, was used to treat TSC related manifestations in Tsc2 knockout mice.METHODS:
The novel object recognition test was used to analyze the recognition memory function. The long-term potentiation was studied using electrophysiological analysis. Western blotting was used to assess the protein expression and activation status.RESULTS:
Recognition memory deficit began as early as 4 weeks of age in both male and female Tsc2+/- mice. Oral administration with SLCP activates AMPK activity and inhibits mTOR activity in the brain tissue of Tsc2+/- mice, and can rescue the electrophysiological abnormality and object recognition memory loss in the mice.CONCLUSIONS:
Our results suggest that SLCP could be an effective treatment for TSC patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esclerose Tuberosa
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Curcumina
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Serina-Treonina Quinases TOR
Limite:
Animals
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Female
/
Humans
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Male
Idioma:
En
Revista:
Phytomedicine
Assunto da revista:
TERAPIAS COMPLEMENTARES
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Taiwan