A new mechanism of action of dipyrone: blockade of the release of a nociceptive factor from macrophages.
Braz J Med Biol Res
; 21(3): 565-8, 1988.
Article
em En
| MEDLINE
| ID: mdl-3067812
ABSTRACT
Rat macrophage monolayers pre-treated with endotoxin release into the incubating fluid a factor (MW greater than 10,000) capable of inducing writhing in mice (MNF). This release was inhibited by dipyrone (3.5-35 micrograms/ml) but not by indomethacin (0.5-2 micrograms/ml). Writhing in mice induced by the factor is blocked by dipyrone (0.5-50 mg/kg) and indomethacin (0.5-2 mg/kg). These results indicate that in addition to the previously described direct blockade of hyperalgesia by dipyrone, this drug may also affect the release of MNF, which induces in vivo nociception through the release of prostaglandin-like substances.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nociceptores
/
Aminopirina
/
Dipirona
/
Indometacina
/
Macrófagos
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Braz J Med Biol Res
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Brasil