Glucose-mediated inhibition of calcium-activated potassium channels limits &#945;-cell calcium influx and glucagon secretion.

Dickerson, Matthew T; Dadi, Prasanna K; Altman, Molly K; Verlage, Kenneth R; Thorson, Ariel S; Jordan, Kelli L; Vierra, Nicholas C; Amarnath, Gautami; Jacobson, David A

Glucose-mediated inhibition of calcium-activated potassium channels limits α-cell calcium influx and glucagon secretion.

Dickerson, Matthew T; Dadi, Prasanna K; Altman, Molly K; Verlage, Kenneth R; Thorson, Ariel S; Jordan, Kelli L; Vierra, Nicholas C; Amarnath, Gautami; Jacobson, David A.

Afiliação

Dickerson MT; Department of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee.
Dadi PK; Department of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee.
Altman MK; Department of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee.
Verlage KR; Department of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee.
Thorson AS; School of Medicine, Texas Tech University Health Sciences Center , Lubbock, Texas.
Jordan KL; Department of Urology, Oregon Health and Science University , Portland, Oregon.
Vierra NC; Department of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee.
Amarnath G; Department of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee.
Jacobson DA; Department of Molecular Physiology and Biophysics, Vanderbilt University , Nashville, Tennessee.

Am J Physiol Endocrinol Metab ; 316(4): E646-E659, 2019 04 01.

Article em En | MEDLINE | ID: mdl-30694690

Assuntos

Canais de Cálcio/metabolismo; Cálcio/metabolismo; Células Secretoras de Glucagon/metabolismo; Glucagon/metabolismo; Glucose/metabolismo; Canais de Potássio Cálcio-Ativados/metabolismo; Alcanos/farmacologia; Animais; Apamina/farmacologia; Canais de Cálcio Tipo L/metabolismo; Canais de Cálcio Tipo P/metabolismo; Canais de Cálcio Tipo Q/metabolismo; Retículo Endoplasmático/metabolismo; Camundongos; Camundongos Transgênicos; Técnicas de Patch-Clamp; Peptídeos/farmacologia; Bloqueadores dos Canais de Potássio/farmacologia; Canais de Potássio Cálcio-Ativados/antagonistas & inibidores; Pirazóis/farmacologia; Compostos de Quinolínio/farmacologia

Palavras-chave

calcium handling; glucagon secretion; potassium channel; α-cell

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glucagon / Canais de Cálcio / Cálcio / Canais de Potássio Cálcio-Ativados / Células Secretoras de Glucagon / Glucose Limite: Animals Idioma: En Revista: Am J Physiol Endocrinol Metab Assunto da revista: ENDOCRINOLOGIA / FISIOLOGIA / METABOLISMO Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google