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The chemical diversity and structure-based discovery of allosteric modulators for the PIF-pocket of protein kinase PDK1.
Xu, Xinyuan; Chen, Yingyi; Fu, Qiang; Ni, Duan; Zhang, Jian; Li, Xiaolong; Lu, Shaoyong.
Afiliação
  • Xu X; a Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education , Shanghai Jiao Tong University, School of Medicine , Shanghai , China.
  • Chen Y; a Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education , Shanghai Jiao Tong University, School of Medicine , Shanghai , China.
  • Fu Q; b Department of Orthopedics , Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine , Shanghai , China.
  • Ni D; a Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education , Shanghai Jiao Tong University, School of Medicine , Shanghai , China.
  • Zhang J; a Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education , Shanghai Jiao Tong University, School of Medicine , Shanghai , China.
  • Li X; c Department of Orthopedics , Changhai Hospital, Naval Military Medical University , Shanghai , China.
  • Lu S; a Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education , Shanghai Jiao Tong University, School of Medicine , Shanghai , China.
J Enzyme Inhib Med Chem ; 34(1): 361-374, 2019 Dec.
Article em En | MEDLINE | ID: mdl-30734603
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Regulação Alostérica / Descoberta de Drogas Limite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Serina-Treonina Quinases / Regulação Alostérica / Descoberta de Drogas Limite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido