Recurrence of oxalate deposition in a renal transplant during ciclosporin A therapy.
Child Nephrol Urol
; 9(1-2): 90-2, 1988.
Article
em En
| MEDLINE
| ID: mdl-3075154
ABSTRACT
A 14.5-year-old boy with end-stage renal failure due to familial primary hyperoxaluria underwent cadaver donor renal transplantation. The graft function was stable for a period of 22 months, while he was on conventional immunosuppressive therapy (prednisolone and azathioprine) and additional oral pyridoxine, phosphorus, and magnesium supplementation. When ciclosporin A was introduced instead of azathioprine, the blood levels of oxalate rose, and oxalate deposition in the renal tubuli became evident. These observations suggest that ciclosporin A interferes with oxalate metabolism and, therefore, should be given with utmost caution in patients with primary hyperoxaluria.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxalatos
/
Hiperoxalúria
/
Hiperoxalúria Primária
/
Transplante de Rim
/
Ciclosporinas
/
Falência Renal Crônica
Limite:
Adolescent
/
Humans
/
Male
Idioma:
En
Revista:
Child Nephrol Urol
Assunto da revista:
NEFROLOGIA
/
PEDIATRIA
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Israel