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Elucidation of the Herbicidin Tailoring Pathway Offers Insights into Its Structural Diversity.
Pan, Hai-Xue; Chen, Zhang; Zeng, Tianfang; Jin, Wen-Bing; Geng, Yujie; Lin, Geng-Min; Zhao, Juan; Li, Wei-Tao; Xiong, Zijun; Huang, Sheng-Xiong; Zhai, Xin; Liu, Hung-Wen; Tang, Gong-Li.
Afiliação
  • Pan HX; State Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry , University of Chinese Academy of Sciences (CAS), CAS, Shanghai 200032 , China.
  • Zeng T; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
  • Jin WB; State Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry , University of Chinese Academy of Sciences (CAS), CAS, Shanghai 200032 , China.
  • Zhao J; State Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry , University of Chinese Academy of Sciences (CAS), CAS, Shanghai 200032 , China.
  • Li WT; State Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry , University of Chinese Academy of Sciences (CAS), CAS, Shanghai 200032 , China.
  • Xiong Z; State Key Laboratory of Phytochemistry and Plant Resources in West China, Center for Excellence in Molecular Plant Sciences , Kunming Institute of Botany , CAS, Kunming 650201 , China.
  • Huang SX; State Key Laboratory of Phytochemistry and Plant Resources in West China, Center for Excellence in Molecular Plant Sciences , Kunming Institute of Botany , CAS, Kunming 650201 , China.
  • Zhai X; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education , Shenyang Pharmaceutical University , Shenyang 110016 , China.
  • Tang GL; State Key Laboratory of Bio-organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry , University of Chinese Academy of Sciences (CAS), CAS, Shanghai 200032 , China.
Org Lett ; 21(5): 1374-1378, 2019 03 01.
Article em En | MEDLINE | ID: mdl-30763106
The biosynthetic gene clusters for herbicidins ( hbc) and aureonuclemycin ( anm) were identified in Streptomyces sp. KIB-027 and Streptomyces aureus, respectively. The roles of genes possibly involved in post-core-assembly steps in herbicidin biosynthesis in these clusters and a related her cluster were studied. Through systematic gene deletions, structural elucidation of the accumulated intermediates in the mutants, and in vitro verification of the encoded enzymes, the peripheral modification pathway for herbicidin biosynthesis is now fully established.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nucleosídeos de Purina / Streptomyces / Antibacterianos Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nucleosídeos de Purina / Streptomyces / Antibacterianos Idioma: En Revista: Org Lett Assunto da revista: BIOQUIMICA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos