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Hyperammonemia From Ureaplasma Infection in an Immunocompromised Child.
Placone, Nicholas; Kao, Roy L; Kempert, Pamela; Ruiz, Maritza E; Casillas, Jacqueline N; Okada, Maki; Gibson, James B; Maggi, Carlos; O'Brien, Kevin; Nattiv, Roy; Gallant, Natalie M; Abrams, Stephanie H.
Afiliação
  • Placone N; Medical College of Wisconsin, Milwaukee, WI.
  • Kao RL; Miller Children's and Women's Hospital Long Beach.
  • Kempert P; Department of Pediatrics, Division of Hematology and Oncology, University of California, Los Angeles.
  • Ruiz ME; Miller Children's and Women's Hospital Long Beach.
  • Casillas JN; Department of Pediatrics, Division of Hematology and Oncology, University of California, Los Angeles.
  • Okada M; Miller Children's and Women's Hospital Long Beach.
  • Gibson JB; Department of Pediatrics, Division of Hematology and Oncology, University of California, Los Angeles.
  • Maggi C; Miller Children's and Women's Hospital Long Beach.
  • O'Brien K; Department of Pediatrics, Division of Hematology and Oncology, University of California, Los Angeles.
  • Nattiv R; Miller Children's and Women's Hospital Long Beach.
  • Gallant NM; Dell Children's Medical Center, Austin, TX.
  • Abrams SH; Miller Children's and Women's Hospital Long Beach.
J Pediatr Hematol Oncol ; 42(2): e114-e116, 2020 03.
Article em En | MEDLINE | ID: mdl-30789458
Idiopathic hyperammonemia is a rare, poorly understood, and often lethal condition that has been described in immunocompromised patients. This report describes an immunocompromised patient with acute myelogenous leukemia who developed persistent hyperammonemia up to 705 µmol/L (normal, 0 to 47 µmol/L) refractory to multiple different therapies. However, after beginning azithromycin and then doxycycline therapy for Ureaplasma species infection, the patient showed immediate and sustained clinical improvement and resolution of ammonia levels. Recognizing disseminated Ureaplasma species infection as a potential cause of idiopathic hyperammonemia, an unexplained, often fatal condition in immunocompromised patients, and empirically treating for this infection could potentially be lifesaving.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ureaplasma / Leucemia Mieloide Aguda / Protocolos de Quimioterapia Combinada Antineoplásica / Infecções por Ureaplasma / Hospedeiro Imunocomprometido / Hiperamonemia / Quimioterapia de Indução Tipo de estudo: Prognostic_studies Limite: Adolescent / Female / Humans Idioma: En Revista: J Pediatr Hematol Oncol Assunto da revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ureaplasma / Leucemia Mieloide Aguda / Protocolos de Quimioterapia Combinada Antineoplásica / Infecções por Ureaplasma / Hospedeiro Imunocomprometido / Hiperamonemia / Quimioterapia de Indução Tipo de estudo: Prognostic_studies Limite: Adolescent / Female / Humans Idioma: En Revista: J Pediatr Hematol Oncol Assunto da revista: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Ano de publicação: 2020 Tipo de documento: Article País de publicação: Estados Unidos