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Dual blockade of CXCL12-CXCR4 and PD-1-PD-L1 pathways prolongs survival of ovarian tumor-bearing mice by prevention of immunosuppression in the tumor microenvironment.
Zeng, Yang; Li, Binghao; Liang, Yingying; Reeves, Patrick M; Qu, Xiying; Ran, Chongzhao; Liu, Qiuyan; Callahan, Michael V; Sluder, Ann E; Gelfand, Jeffrey A; Chen, Huabiao; Poznansky, Mark C.
Afiliação
  • Zeng Y; Vaccine and Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
  • Li B; Vaccine and Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
  • Liang Y; Vaccine and Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
  • Reeves PM; Vaccine and Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
  • Qu X; Vaccine and Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
  • Ran C; Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA; and.
  • Liu Q; National Key Laboratory of Medical Immunology, Second Military Medical University, Shanghai, China.
  • Callahan MV; Vaccine and Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
  • Sluder AE; Vaccine and Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
  • Gelfand JA; Vaccine and Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
  • Chen H; Vaccine and Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
  • Poznansky MC; Vaccine and Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
FASEB J ; 33(5): 6596-6608, 2019 05.
Article em En | MEDLINE | ID: mdl-30802149
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Transdução de Sinais / Receptores CXCR4 / Quimiocina CXCL12 / Microambiente Tumoral / Antígeno B7-H1 / Receptor de Morte Celular Programada 1 / Compostos Heterocíclicos / Tolerância Imunológica / Proteínas de Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Transdução de Sinais / Receptores CXCR4 / Quimiocina CXCL12 / Microambiente Tumoral / Antígeno B7-H1 / Receptor de Morte Celular Programada 1 / Compostos Heterocíclicos / Tolerância Imunológica / Proteínas de Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: FASEB J Assunto da revista: BIOLOGIA / FISIOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos