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Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos.
Zuo, Erwei; Sun, Yidi; Wei, Wu; Yuan, Tanglong; Ying, Wenqin; Sun, Hao; Yuan, Liyun; Steinmetz, Lars M; Li, Yixue; Yang, Hui.
Afiliação
  • Zuo E; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai Institutes for Biological Sciences, Ch
  • Sun Y; Center for Animal Genomics, Agricultural Genome Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518124, China.
  • Wei W; CAS Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China.
  • Yuan T; Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
  • Ying W; Stanford Genome Technology Center, Stanford University, Palo Alto, CA 94304, USA.
  • Sun H; Center for Biomedical Informatics, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai 200040, China.
  • Yuan L; Center for Animal Genomics, Agricultural Genome Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen 518124, China.
  • Steinmetz LM; Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai Institutes for Biological Sciences, Ch
  • Li Y; University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0726, USA.
  • Yang H; Key Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Science ; 364(6437): 289-292, 2019 04 19.
Article em En | MEDLINE | ID: mdl-30819928
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Blastômeros / Polimorfismo de Nucleotídeo Único / Citosina / Sistemas CRISPR-Cas / Edição de Genes / Proteína 9 Associada à CRISPR Limite: Animals Idioma: En Revista: Science Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Suíça País de publicação: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Blastômeros / Polimorfismo de Nucleotídeo Único / Citosina / Sistemas CRISPR-Cas / Edição de Genes / Proteína 9 Associada à CRISPR Limite: Animals Idioma: En Revista: Science Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Suíça País de publicação: Estados Unidos