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Repetitive closed-head impact model of engineered rotational acceleration (CHIMERA) injury in rats increases impulsivity, decreases dopaminergic innervation in the olfactory tubercle and generates white matter inflammation, tau phosphorylation and degeneration.
Vonder Haar, Cole; Martens, Kris M; Bashir, Asma; McInnes, Kurt A; Cheng, Wai Hang; Cheung, Honor; Stukas, Sophie; Barron, Carlos; Ladner, Tessa; Welch, Kassandra A; Cripton, Peter A; Winstanley, Catharine A; Wellington, Cheryl L.
Afiliação
  • Vonder Haar C; Injury and Recovery Laboratory, Department of Psychology, West Virginia University, Morgantown, WV 26508, USA; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address: cole.vonderhaar@mail.wvu.edu.
  • Martens KM; Injury and Recovery Laboratory, Department of Psychology, West Virginia University, Morgantown, WV 26508, USA; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address: kris.martens@mail.wvu.edu.
  • Bashir A; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address: asma.bashir@ubc.ca.
  • McInnes KA; International Centre On Repair Discoveries, Department of Mechanical Engineering, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.
  • Cheng WH; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
  • Cheung H; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
  • Stukas S; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address: sophie.stukas@ubc.ca.
  • Barron C; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address: cbe37@mail.ubc.ca.
  • Ladner T; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
  • Welch KA; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
  • Cripton PA; International Centre On Repair Discoveries, Department of Mechanical Engineering, University of British Columbia, Vancouver, BC V5Z 1M9, Canada. Electronic address: cripton@mech.ubc.ca.
  • Winstanley CA; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address: cwinstanley@psych.ubc.ca.
  • Wellington CL; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address: wcheryl@mail.ubc.ca.
Exp Neurol ; 317: 87-99, 2019 07.
Article em En | MEDLINE | ID: mdl-30822421
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismos Cranianos Fechados / Proteínas tau / Neurônios Dopaminérgicos / Substância Branca / Tubérculo Olfatório / Inflamação Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Exp Neurol Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismos Cranianos Fechados / Proteínas tau / Neurônios Dopaminérgicos / Substância Branca / Tubérculo Olfatório / Inflamação Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Exp Neurol Ano de publicação: 2019 Tipo de documento: Article País de publicação: Estados Unidos