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Synthesis of Bioreducible Polycations with Controlled Topologies.
You, Ye-Zi; Yan, Jun-Jie; Yu, Fei; Yu, Zhi-Qiang; Oupicky, David.
Afiliação
  • You YZ; CAS Key Lab of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, China.
  • Yan JJ; CAS Key Lab of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, China.
  • Yu F; University of Nebraska Medical Center, Omaha, NE, USA.
  • Yu ZQ; CAS Key Lab of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, China.
  • Oupicky D; University of Nebraska Medical Center, Omaha, NE, USA. david.oupicky@unmc.edu.
Methods Mol Biol ; 1943: 27-38, 2019.
Article em En | MEDLINE | ID: mdl-30838607
Bioreducible polycations, which possess disulfide linkages in the backbone, have emerged as promising nucleic acid delivery carriers due to their high stability in extracellular physiological condition and bioreduction-triggered release of the genetic material. Further benefits of bioreducible polycations include decreased cytotoxicity due to intracellular reducing environment in the cytoplasm that contains high levels of reducing molecules such as glutathione. Here, we describe the synthesis of bioreducible polycations with emphasis on methods to control their topology.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliaminas / Portadores de Fármacos / Polimerização Idioma: En Revista: Methods Mol Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poliaminas / Portadores de Fármacos / Polimerização Idioma: En Revista: Methods Mol Biol Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos