Synthesis of Bioreducible Polycations with Controlled Topologies.
Methods Mol Biol
; 1943: 27-38, 2019.
Article
em En
| MEDLINE
| ID: mdl-30838607
Bioreducible polycations, which possess disulfide linkages in the backbone, have emerged as promising nucleic acid delivery carriers due to their high stability in extracellular physiological condition and bioreduction-triggered release of the genetic material. Further benefits of bioreducible polycations include decreased cytotoxicity due to intracellular reducing environment in the cytoplasm that contains high levels of reducing molecules such as glutathione. Here, we describe the synthesis of bioreducible polycations with emphasis on methods to control their topology.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Poliaminas
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Portadores de Fármacos
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Polimerização
Idioma:
En
Revista:
Methods Mol Biol
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
Estados Unidos