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Changes in substance P levels of inferior turbinate in patients with mucosal contact headache.
Eyigör, Hülya; Eyigör, Mete; Erol, Bekir; Selçuk, Ömer Tarik; Renda, Levent; Yilmaz, Mustafa Deniz; Osma, Üstün; Demirkiran, Cansu; Gültekin, Meral; Erin, Nuray.
Afiliação
  • Eyigör H; Antalya Education and Research Hospital, Department of Ear-Nose-Throat Head and Neck Surgery, Antalya, Turkey.
  • Eyigör M; Akdeniz University Medical Faculty, Department of Medical Microbiology, Antalya, Turkey. Electronic address: meyigor@akdeniz.edu.tr.
  • Erol B; Antalya Education and Research Hospital, Department of Radiology, Antalya, Turkey.
  • Selçuk ÖT; Antalya Education and Research Hospital, Department of Ear-Nose-Throat Head and Neck Surgery, Antalya, Turkey.
  • Renda L; Antalya Education and Research Hospital, Department of Ear-Nose-Throat Head and Neck Surgery, Antalya, Turkey.
  • Yilmaz MD; Antalya Education and Research Hospital, Department of Ear-Nose-Throat Head and Neck Surgery, Antalya, Turkey.
  • Osma Ü; Antalya Education and Research Hospital, Department of Ear-Nose-Throat Head and Neck Surgery, Antalya, Turkey.
  • Demirkiran C; Antalya Education and Research Hospital, Department of Ear-Nose-Throat Head and Neck Surgery, Antalya, Turkey.
  • Gültekin M; Akdeniz University Medical Faculty, Department of Medical Microbiology, Antalya, Turkey.
  • Erin N; Akdeniz University Medical Faculty, Department of Medical Pharmacology, Antalya, Turkey.
Braz J Otorhinolaryngol ; 86(4): 450-455, 2020.
Article em En | MEDLINE | ID: mdl-30846421
INTRODUCTION: Mucosal contact headache is a referred pain that arises from contact between the nasal septum and the lateral nasal wall. Evidence supports the role of substance P in a contact headache such that release of substance P from sensory nerve endings causes inflammation and allergy. OBJECTIVES: This study aimed to determine possible differences in substance P levels in inferior turbinate hypertrophy creating a contact headache. METHODS: 28 patients who had contact headaches (study group) and 16 volunteers with no complaints were included in the study. Substance P levels in the inferior turbinate tissue samples were quantified using a commercially available substance P EIA kit. RESULTS: In the study group average substance P levels were 2.65±0.27pg/mg tissue (range: 0.61-5.44) and in the control group it was 1.77±0.27pg/mg tissue (range: 0.11-4.35). The difference was statistically significant between the two groups (p=0.0215). Average preoperative headache group visual analog scale scores was 5.93±0.38 (2-9) and the turbinate volume was 6.56±0.35cm3 (3.50-10.30). The control group turbinate volume was 4.71±0.39cm3 (2.50-7.70). We found a correlation between the visual analog scale scores and substance P levels such that substance P levels were higher in visual analog scale scores above 5 (p=0.001). CONCLUSION: This study demonstrates the relationship between intranasal contact headaches and increased mucosal substance P levels. We also found that there is no correlation with substance P levels and volume of the inferior turbinate.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cefaleia Limite: Humans Idioma: En Revista: Braz J Otorhinolaryngol Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cefaleia Limite: Humans Idioma: En Revista: Braz J Otorhinolaryngol Assunto da revista: OTORRINOLARINGOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Turquia País de publicação: Brasil